Download GTU B.Pharma 2018 Summer 5th Sem 2250003 Pharmaceutical Analysis Iii Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 5th Sem 2250003 Pharmaceutical Analysis Iii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER?5 ? EXAMINATION ? SUMMER -2018
Subject Code: 2250003 Date: 18/05/2018
Subject Name: Pharmaceutical Analysis III
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Derive Beer-Lambert's law and explain various types of deviations from Beers 06
Lambert's law.

(b) Draw a labeled diagram of UV-Visible spectrophotometer. Explain various 05
applications of UV- Visible spectrophotometry.

(c) One tablet of drug (mol. wt.: 250, = 710) when dissolved and diluted to 2000 05
ml with water gave absorbance of 0.725 at 275 nm. Calculate mg of drug
present in one tablet.



Q.2 (a) Explain the effect of vibrational coupling, H-bonding and electronic factors on 06
vibrational frequency in IR spectroscopy.

(b) Explain instrumentation of FTIR along with its advantages.
05

(c) Write a brief note on thermal detectors.
05



Q.3 (a) Define chemical shift. Explain various factors affecting chemical shift.
06

(b) Explain theory and principle of NMR spectroscopy.
05

(c) Differentiate:
05
1. Proton and C13 NMR spectroscopy
2. Fluorescence and Phosphorescence



Q.4 (a) Explain various factors affecting fluorescence intensity.
06

(b) Write a brief note on instrumentation of flourimetry.
05

(c) Describe sample handling in IR spectroscopy.
05



Q.5 (a) Explain various interferences in atomic absorption spectrophotometry and 06
various approaches for its minimization.

(b) Write a brief note on photomultiplier tube.
05

(c) Explain different types of nebulizer burner system in flame photometry.
05



Q. 6 (a) Define: molecular ion, daughter ion, base ion and metastable ion. Explain in 06
brief principle and application of mass spectroscopy.

(b) What is hard and soft source. Explain any one soft source in detail.
05

(c) What is resolution of mass analyzer. Explain briefly time of flight analyzer.
05



Q.7 (a) Explain various rules for fragmentation in Mass spectroscopy.
06

(b) Define : Line spectra, Band spectra, wavelength, wave number, frequency
05

(c) How many numbers of signals and multiplets will appear for ethyl chloride and 05
propyl bromide in Proton NMR spectroscopy?
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