Download GTU B.Pharma 2018 Summer 5th Sem 250004 Pharmaceutical Chemistry Vi (Medicinal) Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY

B. Pharm. - SEMESTER-5 EXAMINATION - SUMMER -2018

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Subject Code: 250004 Date: 21/05/2018

Subject Name: Pharmaceutical Chemistry - VI (Medicinal)

Time: 02:30 PM TO 05:30 PM Total Marks: 80

Instructions:

1. Attempt any five questions.

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2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

1. 1. How the following physicochemical properties of drug molecules influence the biological activity. (i) Protein binding (ii) Partition coefficient [06]
   2. Define 1) Bioisosterism ii) Geometrical Isomerism iii) Optical isomerism [05]
   3. Write notes on (i) Hydrogen bonding (ii) Redox potential [05]

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2. 1. Complete the following reactions [06]
      1. Furan + ammonia Al2O3
      2. Pyrrole + chloroform Base
      3. Isoquinoline O2, Permanganate

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   2. Write the synthesis with mechanism of the following [05]
      1. Skraup Quinoline synthesis
      2. Fischer-Indole synthesis
   3. Give the reactions of thiazole and pyrimidine [05]

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3. 1. Define antiasthmatics. Classify and give structure from each classification. [06]
   2. Write a note on (i) Antitussive agent (ii) Decongestants [05]
   3. Discuss SAR of (i) Ranitidine (ii) Omeprazole [05]
4. 1. Write the uses of the following drugs: (i) Noscapine (ii) Triamcinolone (iii) Dimenhydrinate (iv) Methyl cellulose (v) Diphenoxylate (vi) Papaverine [06]

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   2. Write notes on (i) Carminatives (ii) Prokinetics [05]
   3. Give the synthesis of (i) Ranitidine (ii) Omeprazole [05]
5. 1. Give the synthesis of the following drugs (i) Diphenhydramine (ii) Tripelennamine (iii) Antazoline [06]
   2. Write notes on 1) Antiemetics ii) Laxatives [05]

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   3. Discuss the SAR of antihistamines [05]
6. 1. What are Eicossanoids ? Classify with example. Discuss the biosynthesis and pharmacological activities of prostaglandins [06]
   2. Give the synthesis and IUPAC name of (i) Cetrizine (ii) Trimeprazine [05]
   3. Write a note on (i) Local colorectal preparations (ii) Enzymes [05]

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7. 1. Define and classify diagnostic agents. Write a note on sodium Iothalamate and diatrizoic acid [06]
   2. Discuss the following (i) Mannich reaction of indole (ii) Sulphonation of pyridine [05]
   3. Write the reactions of the following (i) Quinoline (ii) Imidazole [05]

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