Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 6th Sem 2260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry Ii) Previous Question Paper
Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER?6 ? EXAMINATION ? SUMMER -2018
Subject Code:2260004
Date:08/05/2018
Subject Name: Pharmaceutical Chemistry VIII (Medicinal Chemistry II)
Time: 10:30AM TO 01:30PM
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Write down Phase I metabolism in detail.
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(b) Write a note on CYP450.
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(c) What are the factors affecting drug metabolism.
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Q.2 (a) Explain the theory of receptors in detail.
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(b) Write a note on Phase II metabolism.
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(c) Explain factors affecting the drug-receptor interactions
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Q.3 (a) Give chemical classification of Antipsychotics and discuss the SAR of
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Phenothiazine.
(b) Write down SAR of Tricyclic Antidepressant agents.
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(c) Give IUPAC name and synthesis of Fluoxetine and Imipramine.
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Q.4 (a) Classify barbiturates with examples. Give SAR of barbiturates.
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(b) What are DMARDS? Give synthesis of Paracetamol.
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(c) Give IUPAC name and synthesis of Halothane and Lignocaine.
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Q.5 (a) What are antiepileptic drugs? Give them mechanism of action. Classify with
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examples.
(b) Write SAR of butyrophenones.
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(c) Give IUPAC name and synthesis of Phenytoin and Carbamazepine.
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Q. 6 (a) Write a note on Antiparkinson's agents with examples.
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(b) Write a short note on cognition enhancer.
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(c) Write a short note Alzheimers disease.
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Q.7 (a) What are NSAIDS? Classify them with examples giving one structure from
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each class.
(b) Write a note on Anti-Gout agents.
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(c) Give IUPAC name and synthesis of Diclofenac and Ibuprofen.
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This post was last modified on 05 March 2021