Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.Pharm. - SEMESTER-VI EXAMINATION - SUMMER-2018
Subject Code:260004 Date: 08/05/2018
Subject Name: Pharmaceutical chemistry-VIII (Medicinal chemistry)
Time:10:30am to 01:30pm Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Give major pathways of drug metabolism. Explain phase-I reactions in brief. 06
(b) What do you mean by drug metabolism? Discuss in brief factors affecting drug 05 metabolism.
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(c) What do you mean by CYP 450? Give its functions and importance. 05
Q.2 (a) Define receptors. Explain occupational theory and induced fit theory of 06 receptors.
(b) Enlist factors affecting drug-receptor interaction. Explain them in brief. 05
(c) Match the followings: (A-B) (Drug-category) 05
A (Drug) B (Category)
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1) Phenytoin A) Antidepressant
2) Amitriptyline B) Opiod analgesic
3) Diclofenac C) Antiepileptic
4) Morphine D) Cholinergic agonist
5) Salbutamol E) NSAIDs
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F) Adrenergic antagonist
Q.3 (a) Define parasympathomimetics. Classify them with two examples and one 06 structure of each category.
(b) Give synthesis of: (Any two) 05
1). Neostigmine 1i) Dicyclomine iii). Adrenaline
(c) Give short note on neuromuscular blocking agents. 05
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Q.4 (a) Define adrenergic antagonists. Classify them with two examples and one 06 structure of each category.
(b) Give SAR of phenylethanolamines. 05
(c) Classify following drugs in the category of adrenergic agonists and adrenergic 05 antagonists:
Ephedrine, Adrenaline, Atenolol, Noradrenaline, Acebutolol, Isoprenaline,
Guanethidine, Prazocin, Naphazoline, Phenoxybenzamine.
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Q.5 (a) Define sedative and hypnotics. Classify them with two examples and one 06 structure of each category.
(b) Give SAR of tricyclic antidepressants. 05
(c) Give short note on cognition enhancers. 05
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Q.6 (a) Define NSAIDs. Classify them with two examples and one structure of each 06 category.
(b) Give short note on antiparkinson’s agents. 05
(c) Give synthesis of: (Any two) 05
1). Paracetamol ii). Chlorpromazine iii). Thiopental sodium.
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Q.7 (a) Define antiepileptics. Classify them with two examples and one structure of 06 each category.
(b) Give SAR of phenothiazines. 05
(c) Give synthesis of: (Any two) 05
1). Amphetamine ii). Phenobarbitone 1iii). Lignocine
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This download link is referred from the post: GTU B.Pharma 2018 Summer Question Papers || Gujarat Technological University
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