Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 6th Sem 260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry) Previous Question Paper
Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm. - SEMESTER?VI ? EXAMINATION ? SUMMER-2018
Subject Code:260004
Date: 08/05/2018
Subject Name: Pharmaceutical chemistry-VIII (Medicinal chemistry)
Time:10:30am to 01:30pm
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Give major pathways of drug metabolism. Explain phase-I reactions in brief.
06
(b) What do you mean by drug metabolism? Discuss in brief factors affecting drug 05
metabolism.
(c) What do you mean by CYP 450? Give its functions and importance.
05
Q.2 (a) Define receptors. Explain occupational theory and induced fit theory of 06
receptors.
(b) Enlist factors affecting drug-receptor interaction. Explain them in brief.
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(c) Match the followings: (A-B) (Drug-category)
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A (Drug)
B (Category)
1) Phenytoin
A) Antidepressant
2) Amitriptyline
B) Opiod analgesic
3) Diclofenac
C) Antiepileptic
4) Morphine
D) Cholinergic agonist
5) Salbutamol
E) NSAIDs
F) Adrenergic antagonist
Q.3 (a) Define parasympathomimetics. Classify them with two examples and one 06
structure of each category.
(b) Give synthesis of: (Any two)
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i). Neostigmine ii) Dicyclomine iii). Adrenaline
(c) Give short note on neuromuscular blocking agents.
05
Q.4 (a) Define adrenergic antagonists. Classify them with two examples and one 06
structure of each category.
(b) Give SAR of phenylethanolamines.
05
(c) Classify following drugs in the category of adrenergic agonists and adrenergic 05
antagonists:
Ephedrine, Adrenaline, Atenolol, Noradrenaline, Acebutolol, Isoprenaline,
Guanethidine, Prazocin, Naphazoline, Phenoxybenzamine.
Q.5 (a) Define sedative and hypnotics. Classify them with two examples and one 06
structure of each category.
(b) Give SAR of tricyclic antidepressants.
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(c) Give short note on cognition enhancers.
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Q. 6 (a) Define NSAIDs. Classify them with two examples and one structure of each 06
category.
(b) Give short note on antiparkinson's agents.
05
(c) Give synthesis of: (Any two)
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i). Paracetamol ii). Chlorpromazine iii). Thiopental sodium.
Q.7 (a) Define antiepileptics. Classify them with two examples and one structure of 06
each category.
(b) Give SAR of phenothiazines.
05
(c) Give synthesis of: (Any two)
05
i). Amphetamine ii). Phenobarbitone iii). Lignocine
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This post was last modified on 05 March 2021