Download GTU B.Pharma 2018 Summer 7th Sem 2270001 Dosage Form Design I Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 7th Sem 2270001 Dosage Form Design I Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER?7 ? EXAMINATION ? SUMMER -2018
Subject Code: 2270001 Date: 19/05/2018
Subject Name: Dosage form Design I
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) What is binder? Discuss the effect of binder on formulation of Pharmaceutical
06
product.

(b) What is Disintegrant. Give the mechanism of and Factor affecting disintegrant
05
on formulation of pharmaceutical product.

(c) Write a note on effect of emulsifying and suspending agent on Pharmaceutical
05
formulation.



Q.2 (a) How does particle size influence GI absorption of drugs? Explain with suitable
06
example.

(b) Writes the importance of physical forms in drug absorption. Explain with
05
suitable example.

(c) Explain the characteristics of Active transport process. Write their application
05
in the development of formulation and administration of drugs.



Q.3 (a) Define Preformulation? Give its importance.
06

(b) Enumerate the drug degradation pathways and discuss Hydrolysis in detail.
05

(c) Write notes on physicochemical parameters studied in preformulation study.
05



Q.4 (a) Explain world climatic zones as per ICH guidelines.
06

(b) Discuss Brackating and Matrixing in brief.
05

(c) Discuss the factors affecting stability of drug.
05



Q.5 (a) What is BCS? Classify and give the significance of this system
06

(b) Explain USP dissolution apparatus III, IV and V with diagram.
05

(c) What is IVIVC? Describe In-vitro - In-vivo correlations levels.
05



Q. 6 (a) Write a note on similarity factor and dissimilarity factor.
06

(b) Explain: 1) Shelf life 2) Overages 3) Climatic Zones
05

(c) Discuss pH ?Partition hypothesis briefly with suitable examples. Enumerate the 05
assumptions of this hypothesis.



Q.7 (a) Give its objectives & classification of BCS. Give condition for justifying
06
request of biowaiver.

(b) Discuss Brackating and Matrixing in brief.
05

(c) Enumerates factors affecting dissolution of drug, discuss factors related to drug
05
product formulation.
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