GTU B.Pharma 2018 Summer Question Papers || Gujarat Technological University
Seat No.:
Subject Code: 2280001
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Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER-8 EXAMINATION — SUMMER -2018
Subject Name: Dosage form Design 11
Time: 10:30 AM TO 01:30 PM
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
| Q.1 | (a) | Enlist various methods of preparation of microspheres and explain double emulsion method in detail. | 06 |
| (b) | Explain influence of extraction ratio in hepatic clearance. | 05 | |
| (c) | Enlist different types of hydrogels and explain in situ gel in detail. | 05 | |
| Q.2 | (a) | Enumerate various parenteral drug delivery system and explain any one in detail. | 06 |
| (b) | Write short note on Michaeles Menton Equation. | 05 | |
| (c) | Explain importance of tortuosity and porosity in dissolution. | 05 | |
| Q.3 | (a) | Write a note on pharmacokinetic drug interactions with examples. | 06 |
| (b) | Discuss ideal characteristics of drug eligible for transdermal drug delivery system. | 05 | |
| (c) | Explain lag time and burst effect in controlled drug delivery system with diagram. | 05 | |
| Q.4 | (a) | Explain catenary and mammillary compartment models in detail. | 06 |
| (b) | Briefly explain colon targeted osmotic drug delivery system. | 05 | |
| (c) | Discuss in brief; effect of disease on colonic absorption of drugs. | 05 | |
| Q.5 | (a) | Explain in detail, evaluation parameters of transdermal patch. | 06 |
| (b) | Differentiate liposomes and niosomes. | 05 | |
| (c) | Write a note on reservoir type of controlled drug delivery system. | 05 | |
| Q.6 | (a) | Enlist different types of targeted drug delivery system and explain any one in detail. | 06 |
| (b) | Give example of hydrophobic type of matrix system and explain mechanism of drug release from it. | 05 | |
| (c) | Explain appropriately with equations if necessary, dosage adjustment in patients with renal failure. | 05 | |
| Q.7 | (a) | Write short note on Pulsincap with appropriate figure. | 06 |
| (b) | Elaborate effervescent system in GRDDS. | 05 | |
| (c) | Define Cmax, Volume of distribution, compartment model, Total clearance and Clinical pharmacokinetics. | 05 |
Total Marks: 80
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Date: 28/04/2018
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