Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM SEMESTER VIII - EXAMINATION - WINTER-2017Subject Code: 2280001 Date: 02/11/2017
Subject Name: Dosage Form Design-11
Time: 02:30 pm to 5:30 pm Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Enumerate the factors affecting the designing of oral sustained release drug 06 delivery systems and explain any one in detail.
(b) Discuss the merits and demerits of controlled release formulation 05
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(c) What are loading and maintenance dose? How are they calculated? 05
Q.2 (a) Write a note on dissolution and diffusion controlled release system 06
(b) Describe the key components of osmotic drug delivery system with examples. 05
(c) Write a note on colon targeted drug delivery system. 05
Q.3 (a) Discuss the various formulation approaches for floating drug delivery systems. 06
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(b) Write about In-vitro-In-vivo evaluations of floating drug delivery systems. 05
(c) Explain pH Sensitive and Prodrug approach to develop colonic Drug Delivery 05 Systems in brief.
Q.4 (a) Write in brief about OROS-CT and EOP: 06
(b) Discuss in detail about PULSINCAP.Technology. 05
(c) Write a note on: Microspheres. 05
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Q.5 (a) Describe formulation and evaluation of transdermal drug delivery system. 06
(b) Define liposomes and niosomes. Describe their evaluation. 05
(c) Write a note on: Hydrogel. 05
Q.6 (a) What are pharmacokinetic models? Explain in detail one compartment model. 06
(b) Describe the method of residuals for determination of absorption rate constant. 05
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(c) Explain Wagner nelson method in detail. 05
Q.7 (a) Explain how one can detect nonlinear pharmacokinetics? Explain Michaelis 06 Menten equation for capacity limited process.
(b) Define clinical pharmacokinetics. Explain dosage adjustment in patients with 05 renal failure.
(c) Explain term: Drug interaction. Discuss ADME drug interactions with suitable 05 examples.
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