Download GTU B.Pharma 2017 Winter 8th Sem 2280001 Dosage Form Design Ii Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2017 Winter 8th Sem 2280001 Dosage Form Design Ii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER VIII ? EXAMINATION ? WINTER-2017

Subject Code: 2280001
Date: 02/11/2017
Subject Name: Dosage Form Design-II
Time: 02:30 pm to 5:30 pm
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Enumerate the factors affecting the designing of oral sustained release drug
06
delivery systems and explain any one in detail.

(b) Discuss the merits and demerits of controlled release formulation
05

(c) What are loading and maintenance dose? How are they calculated?
05



Q.2 (a) Write a note on dissolution and diffusion controlled release system
06

(b) Describe the key components of osmotic drug delivery system with examples.
05

(c) Write a note on colon targeted drug delivery system.
05



Q.3 (a) Discuss the various formulation approaches for floating drug delivery systems.
06

(b) Write about In-vitro-In-vivo evaluations of floating drug delivery systems.
05

(c) Explain pH Sensitive and Prodrug approach to develop colonic Drug Delivery
05
Systems in brief.



Q.4 (a) Write in brief about OROS-CT and EOP.
06

(b) Discuss in detail about PULSINCAP Technology.
05

(c) Write a note on: Microspheres.
05



Q.5 (a) Describe formulation and evaluation of transdermal drug delivery system.
06

(b) Define liposomes and niosomes. Describe their evaluation.
05

(c) Write a note on: Hydrogel.
05



Q. 6 (a) What are pharmacokinetic models? Explain in detail one compartment model.
06

(b) Describe the method of residuals for determination of absorption rate constant.
05

(c) Explain Wagner nelson method in detail.
05



Q.7 (a) Explain how one can detect nonlinear pharmacokinetics? Explain Michaelis
06
Menten equation for capacity limited process.

(b) Define clinical pharmacokinetics. Explain dosage adjustment in patients with
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renal failure.

(c) Explain term: Drug interaction. Discuss ADME drug interactions with suitable
05
examples.
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