Download Pharm D 1st Year 2012 April 383804 Pharmaceutical Organic Chemistry Question Paper

Download Pharm-D (Doctor of Pharmacy) 1st Year (First Year) 2012 April 383804 Pharmaceutical Organic Chemistry Previous Question Paper

[LA 804] APRIL 2012 Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER IV ? PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. a) Elaborate the mechanism , kinetic and stereochemistry
of aliphatic nucleophilic Substitution (SN
1
and SN
2
) reaction.
b) Explain about the role of phase transfer catalysis in
substitution reaction. 17 40 min. 20
2. a) Illustrate about the Kinetic, mechanism and isotopic
effect of E1and E2 reactions.
b) Add a note on dehydration of acid catalysis. 17 40 min. 20
II. Write notes on :
1. Give an account of acid and base on the basis of Lewis theories. 4 10 min. 6
2. Preparation, test for purity, assay and uses of vanillin. 4 10 min. 6
3. Explain the mechanism of halogenations of alkanes.
Give the evidence for the same. 4 10 min. 6
4. Outline any two methods of conversion of acids to acid
chloride and amide. 4 10 min. 6
5. Discuss the mechanism and synthetic uses of benzoin
condensation reaction. 4 10 min. 6
6. Describe the preparation methods for esters. 4 10 min. 6
7. Outline briefly about Bayer strain theory. 4 10 min. 6
8. Discuss the mechanism and synthetic uses of witting reaction. 4 10 min. 6
9. Write a note on Diels alder reaction. 4 10 min. 6
10. Preparation, test for purity, assay and uses of Aspirin. 4 10 min. 6

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