Download Pharm D 1st Year 2012 April 383804 Pharmaceutical Organic Chemistry Question Paper

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[LA 804] APRIL 2012 Sub. Code: 3804

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DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION

FIRST YEAR

PAPER IV - PHARMACEUTICAL ORGANIC CHEMISTRY

O.P. Code: 383804

Time: Three Hours Maximum: 100 marks

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Answer ALL questions in the same order.

I. Elaborate on : Pages Time Marks

(Max.) (Max.) (Max.)

1. a) Elaborate the mechanism, kinetic and stereochemistry of aliphatic nucleophilic Substitution (SN¹ and SN²) reaction.
   b) Explain about the role of phase transfer catalysis in substitution reaction. 17 40 min. 20

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2. a) Illustrate about the Kinetic, mechanism and isotopic effect of E1 and E2 reactions.
   b) Add a note on dehydration of acid catalysis. 17 40 min. 20

II. Write notes on :

1. Give an account of acid and base on the basis of Lewis theories. 4 10 min. 6
2. Preparation, test for purity, assay and uses of vanillin. 4 10 min. 6

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3. Explain the mechanism of halogenations of alkanes. Give the evidence for the same. 4 10 min. 6
4. Outline any two methods of conversion of acids to acid chloride and amide. 4 10 min. 6
5. Discuss the mechanism and synthetic uses of benzoin condensation reaction. 4 10 min. 6
6. Describe the preparation methods for esters. 4 10 min. 6
7. Outline briefly about Bayer strain theory. 4 10 min. 6

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8. Discuss the mechanism and synthetic uses of witting reaction. 4 10 min. 6
9. Write a note on Diels alder reaction. 4 10 min. 6
10. Preparation, test for purity, assay and uses of Aspirin. 4 10 min. 6