Download Pharm D 4th Year 2014 April 383823 Biopharmaceutics And Pharmacokinetics Question Paper

FirstRanker.com

Sub. Code: 3823

DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE) DEGREE EXAMINATION

--- Content provided by‍ FirstRanker.com ---

FOURTH YEAR

PAPER V - BIOPHARMACEUTICS AND PHARMACOKINETICS

O.P. Code: 383823

Time: Three Hours Maximum: 70 marks

Answer All questions

--- Content provided by FirstRanker.com ---

1. Elaborate on: (2 x 20 = 40)
   1. Drug elimination.
   2. A 70 kg patient is to be a given a drug by i.v. infusion. The drug has a half life of 22 hours, apparent volume of distribution 15.7 litres and desired steady state plasma concentration is 0.0002 mcg/ml. Assuming one compartment kinetics calculate; time to reach 90% steady state concentration, infusion rate to achieve desired steady state concentration, loading dose to attain steady state rapidly and concentration of drug in plasma after 48 hours from the start of infusion.
2. Write notes on: (10 x 3 = 30)
   1. Enlist physiological barriers for distribution.
   2. Statistical interpretation of bioequivalence data.

   --- Content provided by FirstRanker.com ---

   3. Endocytosis.
   4. Tissue localization.
   5. Plasma level time curve.
   6. Advantages of Catenary model.
   7. Lineweaver-Burke Plot.

   --- Content provided by​ FirstRanker.com ---

   8. Persistance factor and loss factor.
   9. Approaches for dosage regimen.
   10. Dissolution apparatus I.

FirstRanker.com

--- Content provided by‌ FirstRanker.com ---