Download Pharm D 4th Year 2015 April 383823 Biopharmaceutics And Pharmacokinetics Question Paper

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[LG 823] APRIL 2015 Sub. Code: 3823

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DOCTOR OF PHARMACY (PHARM. D/ POST BACCALAUREATE) DEGREE EXAMINATION

(2009-2010 Regulation)

FOURTH YEAR

PAPER V - BIOPHARMACEUTICS AND PHARMACOKINETICS

Q.P. Code: 383823

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Time: Three Hours Maximum: 70 marks

Answer All questions

1. Elaborate on: (4 x 10 = 40)
   1. Pharmaceutical factors influencing G.I.T absorption.
   2. Nonlinear kinetics — Causes and estimation of K_m and V_max.
   3. Bioavailability enhancement through solubility / dissolution rate.

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   4. Pharmacokinetic analysis of mathematical data.
2. Write notes on: (6 x 5 = 30)
   1. Plasma protein bindings.
   2. Apparent Volume of distribution.
   3. Factors affecting renal excretion.

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   4. Statistical Moment Theory.
   5. Plateau principle.
   6. Estimate the creatinine clearance of a 30 year old 70 kg man with serum creatinine level of 2 mg %. What is the renal function of this patient?

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