Pharm D Last 12 Years 2010-2022 Question Papers (1st Year, 2nd Year, 3rd Year, 4th Year and 5th Year)
[LH 823] OCTOBER 2015 Sub. Code: 3823
PHARM. ‘D’ AND PHARM. ‘D’ (POST BACCALAUREATE) DEGREE EXAMINATION (2009-2010 Regulation) FOURTH YEAR PAPER V —- BIOPHARMACEUTICS AND PHARMACOKINETICS
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Q.P. Code : 383823
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on : (4 x 10 = 40)
- One compartment open IV bolus administration.
- Define excretion and explain briefly about renal excretion of drugs.
- Physiological barriers to distribution of drugs.
- In Vitro drug dissolution testing models.
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II. Write notes on : (6 x 5 = 30)
- Approaches for dosage regimen.
- Biopharmaceutical classification systems.
- Line-weaver Burk plot.
- Micro and hybrid constants.
- Tissue localization of drugs.
- A drug is administered at a dose of 500 mg IV bolus injection. The drug has elimination rate constant 0.23 1/hr, volume of distribution is 20 L by following one compartmental kinetics. If Area under the curve is 110 mg hr/L, then calculate mean residence time of the drug.
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