[LL 823] OCTOBER 2017 Sub. Code: 3823
PHARM. ‘D’ AND PHARM. ‘D’ (POST BACCALAUREATE) DEGREE EXAMINATION
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(2009-2010 Regulation)
FOURTH YEAR
PAPER V — BIOPHARMACEUTICS AND PHARMACOKINETICS
O.P. Code: 383823
Time : Three hours Maximum : 70 Marks
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- I. Elaborate on: (4 x 10 =40)
- What are the dosage form related factors affecting drug absorption?
- Explain the volume of distribution with its significance.
- Describe the pharmacokinetics concept involved in repetitive injection in one component open model.
- Enumerate in detail the bio-availability study protocol.
- II. Write notes on: (6x5=30)
- Add a note on statistical moment theory.
- How to determine bio-availability through urinary extraction studies?
- Write about compartment models.
- Discuss the concept involved in clearance.
- Differentiate Phase I and Phase II biotransformation reactions.
- Describe the method of residuals in the determination of absorption rate constant in two compartment open model extra vascular administration.
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