Download Pharm D 4th Year 2018 May Biopharmaceutics And Pharmacokinetics Question Paper

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PHARM. ‘D’ AND PHARM. ‘D’ (POST BACCALAUREATE) DEGREE EXAMINATION (2009-2010 Regulation) FOURTH YEAR PAPER V — BIOPHARMACEUTICS AND PHARMACOKINETICS

Q.P. Code: 383823

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Time : Three hours Maximum : 70 Marks

1. I. Elaborate on: (4 x 10 =40)

   1. Outline the physicochemical factors affecting drug absorption.
   2. Explain the significance of protein/tissue binding of drugs.
   3. Explain Non-linear Pharmacokinetics. Write in estimation of K_m and V_max.

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   4. How to determine pharmacokinetic parameters in one compartment open model intravenous infusion administration?

2. II. Write notes on: (6x5=30)

   1. Differentiate active transport and passive diffusion.
   2. Write the importance of volume of distribution.

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   3. Describe about salivary excretion.
   4. Discuss method of determination and absorption rate constant (Ka).
   5. Write the merits and demerits of non compartmental pharmacokinetics.
   6. Mention the methodology involved in the determination of bioavailability.

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