Pharm D Last 12 Years 2010-2022 Question Papers (1st Year, 2nd Year, 3rd Year, 4th Year and 5th Year)
PHARM. ‘D’ AND PHARM. ‘D’ (POST BACCALAUREATE) DEGREE EXAMINATION (2009-2010 Regulation) FOURTH YEAR
PAPER V — BIOPHARMACEUTICS AND PHARMACOKINETICS
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Time : Three hours Maximum : 70 Marks
I. Elaborate on: (4 x 10 =40)
- Define Pharmacokinetic models and equations of one compartment open model IV Bolus administration.
- Define drug absorption. Discuss the various factors influencing GI absorption of a drug.
- Explain the protocol, procedure for bioequivalence study.
- Discuss the principles that governs the renal excretion of drugs.
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II. Write notes on: (6x5=30)
- Write short note on statistical moment theory
- Discuss causes of non-linearity with example.
- Explain significance of Protein binding.
- Calculate the excretion rate at steady state for a drug given by IV infusion at a rate of 30mg/hr. The Css is 20mcg/ml. If the rate of Infusion were increased to 40mg/hr, what would be the new steady state concentration Css? Would the excretion rate for the drug at the new steady state be the same? Assume first order elimination kinetics and a one compartment model.
- Note on Wagner — Nelson method.
- Describe Blood Brain Barrier.
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