Pharm D Last 12 Years 2010-2022 Question Papers (1st Year, 2nd Year, 3rd Year, 4th Year and 5th Year)
[LD 827] OCTOBER 2013 Sub. Code: 3827
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE) DEGREE EXAMINATION
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FIFTH YEAR
PAPER III - CLINICAL PHARMACOKINETICS AND PHARMACOTHERAPEUTIC DRUG MONITORING
Q.P. Code: 383827
Time: Three Hours Maximum: 70 marks
Answer All questions
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- Elaborate on: (2x20=40)
- Write down the dosing of drugs in the elderly and pediatrics and obese patients with examples.
- Explain Therapeutic drug monitoring. Write about indication and protocol for TDM. Add notes on TDM of drug used in cardiac and seizure disorders.
- Write notes on: (10x 3 =30)
- Write about shifting of Intravenous dose to Oral dose.
- Dosage adjustment in Renal disease.
- Pharmacokinetic drug interaction.
- Analysis of population pharmacokinetic data.
- Inhibition and induction of drug metabolism.
- Discuss the extracorporeal removal of drugs.
- What is genetic polymorphism? Write notes on P-450 Isoenzymes.
- What is individualization of drug dosage regimen?
- Bayesian theory of adaptive method.
- Measurement of Glomerular filtration rate and creatinine clearance.
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