Download Pharm D 5th Year 2013 Oct 383827 Clinical Pharmacokinetics And Pharmacotherapeutic Drug Monitoring Question Paper

Download Pharm-D (Doctor of Pharmacy) 5th Year (Fifth Year) 2013 Oct 383827 Clinical Pharmacokinetics And Pharmacotherapeutic Drug Monitoring Previous Question Paper

[LD 827] OCTOBER 2013 Sub. Code: 3827
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE)
DEGREE EXAMINATION
FIFTH YEAR
PAPER III ? CLINICAL PHARMACOKINETICS AND
PHARMACOTHERAPEUTIC DRUG MONITORING
Q.P. Code: 383827
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (2 x 20 = 40)
1. Write down the dosing of drugs in the elderly and pediatrics and obese patients with
examples.
2. Explain Therapeutic drug monitoring.
Write about indication and protocol for TDM.
Add notes on TDM of drug used in cardiac and seizure disorders.
II. Write notes on: (10 x 3 = 30)
1. Write about shifting of Intravenous dose to Oral dose.
2. Dosage adjustment in Renal disease.
3. Pharmacokinetic drug interaction.
4. Analysis of population pharmacokinetic data.
5. Inhibition and induction of drug metabolism.
6. Discuss the extracorporeal removal of drugs.
7. What is genetic polymorphism? Write notes on P-450 Isoenzymes.
8. What is individualization of drug dosage regimen?
9. Bayesian theory of adaptive method.
10. Measurement of Glomerular filtration rate and creatinine clearance.
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