Pharm D Last 12 Years 2010-2022 Question Papers (1st Year, 2nd Year, 3rd Year, 4th Year and 5th Year)
PAPER III - CLINICAL PHARMACOKINETICS AND PHARMACOTHERAPEUTIC DRUG MONITORING
Q.P. Code: 383827
Time: Three Hours Maximum: 70 marks
Answer All questions
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[LE 827] APRIL 2014 Sub. Code: 3827
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE) DEGREE EXAMINATION
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FIFTH YEARPAPER III - CLINICAL PHARMACOKINETICS AND PHARMACOTHERAPEUTIC DRUG MONITORING
Q.P. Code: 383827
Time: Three Hours Maximum: 70 marks
Answer All questions
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- Elaborate on: (2x20=40)
- Explain the dose adjustment in renal disease with respect to total body clearance and elimination rate constant?
- Write a note on dosing of drugs in hepatic disease?
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- Explain dosing with feedback procedure in population pharmacokinetics?
- Discuss in detail the methods adopted in the analysis of population pharmacokinetic data?
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II. Write notes on: (10x 3 =30)
- Write a note on indications for therapeutic drug monitoring.
- How will you calculate the drug dose for neonates, infants and children?
- How will you determine renal dysfunction in patients?
- Write a note on genetic polymorphism in drug metabolism?
- Discuss about regional pharmacokinetics?
- Explain the adverse reactions attributed to genetic differences
- Differentiate Hemodialysis and Hemoperfusion?
- How will you adjust the dose for uremic patients?
- Discuss the importance of Bayesian theory?
- Explain absorption based drug interactions with examples?
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