Download Pharm D 5th Year 2016 Oct 383827 Clinical Pharmacokinetics And Harmacotherapeutic Drug Monitoring Question Paper

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Sub. Code: 3827

PHARM. ‘D’ AND PHARM. ‘D’ (POST BACCALAUREATE) DEGREE EXAMINATION

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(2009-2010 Regulation)

FIFTH YEAR

PAPER III - CLINICAL PHARMACOKINETICS & PHARMACOTHERAPEUTIC DRUG MONITORING

Q.P. Code : 383827

Time : Three hours Maximum : 70 Marks

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1. Elaborate on: (4 x 10 =40)
   1. Explain the pharmacokinetic changes and dose adjustment in Hepatic disease.
   2. Enumerate the various methods of analyzing population pharmacokinetic data.
   3. Explain the inhibition and induction of drug metabolism with example.
   4. Explain the effect of Genetic Polymorphism in drug transport and drug target.

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2. Write notes on: (6x5=30)
   1. Write a note on dosing in Pediatric patient.
   2. Brief about the inhibition of Biliary excretion.
   3. Write the factors to be considered when designing a dosage regimen.
   4. Brief about the measurement of Glomerular Filtration Rate.
   5. Brief about therapeutic drug monitoring of two Cardio Vascular drugs.

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   6. CYP2CI09.