MAY 2019 Sub. Code: 3827
PHARM. ‘D’ AND PHARM. ‘D’ (POST BACCALAUREATE) DEGREE EXAMINATION
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(2009-2010 Regulation)
FIFTH YEAR
PAPER III - CLINICAL PHARMACOKINETICS & PHARMACOTHERAPEUTIC DRUG MONITORING
Q.P. Code : 383827
Time : Three hours Maximum : 70 Marks
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- I. Elaborate on: (4 x 10 =40)
- Dose adjustment in renal disease.
- Effect of genetic polymorphism in drug transport and drug target.
- Methods of analyzing population pharmacokinetic data.
- TDM of drugs related to cardiovascular, seizure, psychiatric and organ transplantation.
- II. Write notes on: (6x5=30)
- Extracorporeal removal of drugs.
- Inhibition of biliary excretion.
- Adaptive method for dosing.
- Conversion of intravenous to oral dosing.
- TDM indications.
- Application of clinical pharmacokinetics.
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