Download MBBS (Bachelor of Medicine, Bachelor of Surgery) Human Anatomy ppt lectures Topic 32 Histology Of Bone Notes. - anatomy ppt free download human anatomy ppt lectures, medicine notes ppt, anatomy handwritten notes pdf, mbbs 1st year anatomy notes pdf download, best anatomy notes pdf, human anatomy notes pdf, anatomy easy notes pdf, anatomy notes online, anatomy short notes, Anatomy ppt, Powerpoint Presentations and lecture notes.
LEARNING OBJECTIVES
Histological Organisation of Bone
Bone Cells and Matrix
Formation of Bone
Intramembranous Ossification
Endochondral Ossification
Reorganisation and Restoration of Bone
STRUCTURE OF LONG BONE
BASED ON BONE MATURITY
Lamellar bone
WOVEN BONE
LAMELLAR BONE
? Lamellar appearance - arrangement of collagen fibres
? Woven bone is weak- repair of fracture
TYPES OF BONE : macroscopically
Trabecular bone :
?Cancellous or spongy bone
?Ends of long bones
Compact bone:
?Forms thick-walled tube of the shaft (or diaphysis)
?A thin layer of compact bone also covers the
epiphyses of long bones.
COMPACT BONE
?Matrix
?Lamellae*
?Lacunae
?Canaliculi
?Haversian Canals
COMPACT BONE- UNSTAINED
?Haversian system - Osteon
?Interstitial lamellae
?Circumferential lamellae
?Endosteal lamellae
?Volkmann's Canals
COMPACT BONE
Schmorl Stained
Ground section - unstained
TRABECULAR BONE
No Haversian systems
PAGET'S DISEASE
Woven bone and Lamellar bone in disorganised manner
BONE MATRIX
?Collagen fibres (about 90% of the organic substance)
?Ground substance- osteonectin, osteocalcin
?Collagen type I
?Hardness of the matrix - inorganic salts
?Calcification - few days to several months.
BONE CELLS
?Osteoprogenitor cells (stem cells)
?Osteoblasts (or bone forming cells)
?Osteocytes
?Osteoclasts
(Haematopoietic cells)
OSTEOCLASTS
?Large (up to 100 ?m)
?Multi-nucleated (up to 50 nuclei in the actual cell)
?Arise by the fusion of monocytes
?Resorption bays/Howship's lacunae
?Stimulated by parathormone
?Inhibited by calcitonin
FORMATION OF BONE: INTRAMEMBRANOUS
?Osteoprogenitor cells
?Osteoblasts - deposit osteoid
?Woven network - no lamellae
?Osteoid calcifies
?Primitive trabecular bone
?Primitive compact bone
?Subsequent reorganisation
INTRAMEMBRANOUS OSSIFICATION
INTRAMEMBRANOUS OSSIFICATION
ENDOCHONDRAL OSSIFICATION
?Cartilage bone model
?Calcification of intercellular substance (ALP)
?Periosteal bud invasion
ENDOCHONDRAL OSSIFICATION
?Osteoprogenitor cells - enter hypertrophied and partial
calcified cartilage
?Mature into osteoblasts
?Deposition of new bone on calcified cartilage
ENDOCHONDRAL OSSIFICATION
ENDOCHONDRAL OSSIFICATION
EPIPHYSEAL PLATE
EPIPHYSEAL PLATE
1. Resting zone
2. Proliferation zone
3. Hypertrophic zone
4. Calcification zone
5. Ossification zone
GROWTH OF BONE
Bone formation and bone resorption go hand in
hand during the growth of bone.
REORGANISATION AND RESTORATION
?During growth period and continues
?Changes of tensile and compressive forces.
?Wear and tear occurring in bone
?Osteoclasts and osteoblasts
?Forms new Haversian system within the matrix of
compact bone.
?Older Haversian systems - interstitial lamellae
?Capillaries and nerves sprout in
OSTEOPOROSIS
WHAT IS COMPACT BONE?
a. Dense bone
b. Woven bone
c. Immature bone
d. Spongy bone
WHAT CELL IS INVOLVED IN BONE RESORPTION?
a. Osteoclast
b. Osteon
c. Osteocyte
d. Osteoid
WHAT TYPE OF BASIC TISSUE TYPE IS
BONE?
a. Epithelium
b. Connective tissue
c. Muscle
d. Bone
WHAT IS WOVEN BONE?
a. Cancellous bone
b. Dense bone
c. Immature bone
d. Spongy bone
WHAT ARE THE SPICULES ON SPONGY
BONE CALLED?
a. Canaliculi
b. Sharpey's fibers
c. Trabeculae
d. Lacuna
WHAT IS BONE FORMATION CALLED WHEN
THE BONE IS FORMED DIRECTLY, WITHOUT
USING A CARTILAGE TEMPLATE?
a. Intraosseous
b. Intramembranous
c. Endochondral
d. Endosteum
WHAT FORMS THE EPIPHYSEAL GROWTH
PLATE?
a. Fibrocartilage
b. Hyaline cartilage
c. Compact bone
d. Spongy bone
This post was last modified on 05 April 2022