Time: 3 Hours Max Marks: 100
Note: Answer all questions.
Give Diagrammatic representation whenever necessary
Multiple Choice Questions: 10 X 1= 10
- Refsum's disease is due to lack of enzymes of
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a) Beta oxidation b) Alpha oxidation
c) Omega oxidation d) Desaturation - The number of high energy phosphates consumed for the activation of fatty
acids in the cytosol is
a) 1 b) 2--- Content provided by FirstRanker.com ---
c) 3 - In competitive inhibition of enzymes
a) Km increases where as b) Km increases where as
Vmax decreases Vmax remains unchanged
c) Vmax increases while Km d) Vmax decreases while--- Content provided by FirstRanker.com ---
decreases Km remains unchanged - All are substrates for gluconeogenesis during starvation, except
a) Alanine b) Glycerol
c) Glutamine d) Acetyl coA - Bacteria are engulfed by the following process
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a) Phagocytosis b) Pinocytosis
c) Exocytosis d) All of the above - Physiological uncouplers of ETC from oxidative phosphorylation
a) Thermogenin b) Thyroxine
c) Long chain FFA d) All the above - Marasmus is characterized by
a) Bilateral pitting edema. b) Sparse, grey colored hair
c) Severe muscle wasting d) All the above - The following food item has the highest glycemic index
a) Rice b) Table Sugar--- Content provided by FirstRanker.com ---
c) Ice Cream d) Legumes - Which of the following trace element has an antioxidant role?
a) Chromium b) Selenium
c) Zinc d) Nickel - Dietary requirement of thiamine increases with higher intake of
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a) Carbohydrates b) Proteins
c) Cholesterol d) Lipids
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Essay/Long Answer Questions: 2x15=30
- A 48-year-old man presented to O.P. with chest pain. Family history shows
that his father died of a heart attack at the age of 46, and his elder brother also--- Content provided by FirstRanker.com ---
gets chest pain occasionally with an inability to climb stairs without significant
chest pain and shortness of breath. His plasma cholesterol was 450 mg/dl.
a) What is the possible diagnosis?
b) What are the different types of Lipoproteins and their biological
significance?--- Content provided by FirstRanker.com ---
c) Discuss the cholesterol metabolism and how it is regulated.
d) Normal values of HDL and LDL cholesterol.
e) Role of statins in the above condition. (1+3+7+2+2) - What do you understand by enzyme inhibition? Discuss in detail the
different types of enzyme inhibition. Add a note on clinical application of--- Content provided by FirstRanker.com ---
competitive enzyme inhibitors. (2+3+5)
Short Answer Questions: 7x6=42
- Describe active transport mechanism. Give two examples where drugs
inhibit active transport. - Describe the components of electron transport chain. Add a note on
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inhibitors of Electron transport chain. - Define PEM (Protein Energy Malnutrition). Write the types, clinical features
and biochemical investigations of PEM. - How the Physician becomes a part of the Health Care System.
- Explain HMP Pathway. What is the significance of this pathway?
- Write the RDA, sources of Vitamin A and describe Wald's visual cycle.
- Enzyme Linked Immunosorbent Assay (ELISA). Its principle and use.
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Very Short Answer Questions: 6x3=18
- Essential fatty acids.
- Write the reference range for the following parameters:
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a. Serum Sodium
b. Serum Aspartate transaminase
c. Plasma glucose (postprandial). - Enumerate three glycogen storage disorders along with the enzymatic
defect. - Antioxidant vitamins.
- Hormonal regulation of calcium level.
- Clinical significance of HBA1C.
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