Download KNRUHS 1st Year MBBS 2024 August MB2019101 Biochemistry Paper I Question Paper

QP. CODE: MB2019101

KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE-506 002

MBBS FIRST YEAR SUPPLEMENTARY EXAMINATIONS: AUGUST, 2024
Biochemistry Paper-I

--- Content provided by FirstRanker.com ---

Time: 3 Hours Max Marks: 100

Note: Answer all questions.
Give Diagrammatic representation whenever necessary

Multiple Choice Questions: 10 X 1= 10

1. Refsum's disease is due to lack of enzymes of
   

   --- Content provided by FirstRanker.com ---

   a) Beta oxidation b) Alpha oxidation
   c) Omega oxidation d) Desaturation
2. The number of high energy phosphates consumed for the activation of fatty
   acids in the cytosol is
   a) 1 b) 2
   

   --- Content provided by FirstRanker.com ---

   c) 3
3. In competitive inhibition of enzymes
   a) Km increases where as b) Km increases where as
   Vmax decreases Vmax remains unchanged
   c) Vmax increases while Km d) Vmax decreases while
   

   --- Content provided by FirstRanker.com ---

   decreases Km remains unchanged
4. All are substrates for gluconeogenesis during starvation, except
   a) Alanine b) Glycerol
   c) Glutamine d) Acetyl coA
5. Bacteria are engulfed by the following process
   

   --- Content provided by FirstRanker.com ---

   a) Phagocytosis b) Pinocytosis
   c) Exocytosis d) All of the above
6. Physiological uncouplers of ETC from oxidative phosphorylation
   a) Thermogenin b) Thyroxine
   c) Long chain FFA d) All the above

--- Content provided by FirstRanker.com ---

7. Marasmus is characterized by
   a) Bilateral pitting edema. b) Sparse, grey colored hair
   c) Severe muscle wasting d) All the above
8. The following food item has the highest glycemic index
   a) Rice b) Table Sugar
   

   --- Content provided by FirstRanker.com ---

   c) Ice Cream d) Legumes
9. Which of the following trace element has an antioxidant role?
   a) Chromium b) Selenium
   c) Zinc d) Nickel
10. Dietary requirement of thiamine increases with higher intake of
    

    --- Content provided by FirstRanker.com ---

    a) Carbohydrates b) Proteins
    c) Cholesterol d) Lipids

Essay/Long Answer Questions: 2x15=30

11. A 48-year-old man presented to O.P. with chest pain. Family history shows
    that his father died of a heart attack at the age of 46, and his elder brother also
    

    --- Content provided by FirstRanker.com ---

    gets chest pain occasionally with an inability to climb stairs without significant
    chest pain and shortness of breath. His plasma cholesterol was 450 mg/dl.
    a) What is the possible diagnosis?
    b) What are the different types of Lipoproteins and their biological
    significance?
    

    --- Content provided by FirstRanker.com ---

    c) Discuss the cholesterol metabolism and how it is regulated.
    d) Normal values of HDL and LDL cholesterol.
    e) Role of statins in the above condition. (1+3+7+2+2)
12. What do you understand by enzyme inhibition? Discuss in detail the
    different types of enzyme inhibition. Add a note on clinical application of
    

    --- Content provided by FirstRanker.com ---

    competitive enzyme inhibitors. (2+3+5)

Short Answer Questions: 7x6=42

13. Describe active transport mechanism. Give two examples where drugs
    inhibit active transport.
14. Describe the components of electron transport chain. Add a note on
    

    --- Content provided by FirstRanker.com ---

    inhibitors of Electron transport chain.
15. Define PEM (Protein Energy Malnutrition). Write the types, clinical features
    and biochemical investigations of PEM.
16. How the Physician becomes a part of the Health Care System.
17. Explain HMP Pathway. What is the significance of this pathway?

--- Content provided by FirstRanker.com ---

18. Write the RDA, sources of Vitamin A and describe Wald's visual cycle.
19. Enzyme Linked Immunosorbent Assay (ELISA). Its principle and use.

Very Short Answer Questions: 6x3=18

20. Essential fatty acids.
21. Write the reference range for the following parameters:
    

    --- Content provided by FirstRanker.com ---

    a. Serum Sodium
    b. Serum Aspartate transaminase
    c. Plasma glucose (postprandial).
22. Enumerate three glycogen storage disorders along with the enzymatic
    defect.

--- Content provided by FirstRanker.com ---

23. Antioxidant vitamins.
24. Hormonal regulation of calcium level.
25. Clinical significance of HBA1C.

Visit FirstRanker.com for more information.

--- Content provided by FirstRanker.com ---