QP. CODE: MB2019101
KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE-506 002
MBBS FIRST YEAR SUPPLEMENTARY EXAMINATIONS: NOVEMBER, 2024
BIOCHEMISTRY PAPER-I
Time: 3 Hours
Note: Answer all questions.
Give Diagrammatic representation whenever necessary
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Max Marks: 100
Multiple Choice Questions: 10x1=10
- Na⁺ -K+ ATPase is the marker enzyme of
- Nucleus
- Plasma Membrane
- Golgi Bodies
- Cytosol
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- Who proposed Fluid Mosaic model of Cell Membrane in 1972
- Darson and Singer
- Frye and Edidin
- Brown and Goldstein
- Singer and Nicholson
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- Eicosanoids includes
- Prostaglandins
- Leukotrienes
- Thromboxane's
- All of the above
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- Which of the following is cardioprotective fatty acid
- Palmitic acid
- Stearic acid
- Propionic acid
- Omega 3 fatty acid
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- Suicidal enzyme is
- Lipoxygenase
- Cyclooxygenase
- Thromboxane synthase
- 5-Nucleosidase
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- Cystic fibrosis results from defective ion channels for
- NA+
- K+
- Cl
- H+
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- Sphingomyelinase deficiency seen in
- Niemann-Pick disease
- Gaucher's disease
- Tay-Sach's disease
- Guillain Barre syndrome
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- The SDA (Specific Dynamic Action) is the highest for the following nutrient
- Proteins
- Fats
- Vitamins
- Carbohydrates
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- Renal rickets is caused by
- Decreased formation of Cholecalciferol
- Increased synthesis of 25- НОС
- Decreased synthesis of calcitriol
- None of the above
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- Daily requirement of lodine for an adult is
- 15-20pg
- 150-200pg
- 800-900pg
- 600-700pg
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Essay/ Long Answer Questions: 2x15=30
- A 50-year-old obese male came to causality with complaints of severe chest pain and breathlessness. He is a known diabetic since 6 years on irregular treatment. His ECG revealed an ST segment elevation. His lipid profile showed the following. T. cholesterol- 320 mg%, LDL cholesterol- 180 mg%, HDL cholesterol- 24 mg%, Triglycerides- 250 mg%
- What is the probable diagnosis.
- Explain in detail the steps involved in synthesis of cholesterol in our body.
- Causes for hypercholesterolemia
- Role of stating to reduce the cholesterol. (1+7+5+2)
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- What is Gluconeogenesis.
- Under what conditions is the process of gluconeogenesis activated in the body
- What are the substances for gluconeogenesis.
- Mention the key enzymes and how is alanine converted to glucose.
- Justify the statement: Gluconeogenesis is not simple reversal of glycolysis. (1+2+2+5+5)
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Short Answer Questions: 7x6=42
- What are the differences between competitive and noncompetitive inhibition. Give two examples for competitive inhibition.
- How the Physician becomes a part of Care System.
- Write in detail on the Protein-Energy malnutrition disorders.
- Describe the principle and applications of electrophoresis.
- Describe the sources, daily requirements and functions of Vitamin D.
- Describe transport mechanisms across the cell membrane.
- Discuss in detail on the inhibitors of ETC and oxidative phosphorylation and a note on inherited disorders of oxidative phosphorylation.
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Very Short Answer Questions: 6x3 =18
- Essential fatty acids.
- What is an allosteric enzyme. And give one example of reaction catalysed by an allosteric enzyme.
- Explain the concept: "HMP pathway is significant in preservation of erythrocyte membrane integrity".
- Lipotropic factors.
- Mention the sources and functions of Iron.
- Mention the dietary importance of Proteins.
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