Time: 3 Hours Max Marks: 100
Note: Answer all questions.
Give Diagrammatic representation whenever necessary
Multiple Choice Questions: 10x1=10
- Name the defective enzyme in maple syrup urine disease (Branched Chain Ketoaciduria)
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a) Cystathionine
b) Phenyl alanine hydroxylase
c) Homogentisic acid oxidase
d) Oxidative decarboxylase - Increased gastric HCI secretion is found in
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a) Zollinger-Ellison syndrome
b) Gastric carcinoma
c) Pernicious anemia
d) Gastritis - The serum enzyme used to evaluate pancreatic function is
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a) Acid phosphatase
b) Amylase
c) Alkaline phosphatase
d) Lactate dehydrogenase - Which of the following enzymes are involved in Biotransformation?
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a) Transaminases
b) Cytochrome P450 enzymes
c) Dehydrogenases
d) Decarboxylases - Which one of the following is not a protein, but an RNA molecule?
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a) Amylase
b) RNA polymerase
c) Urokinase
d) Reverse transcriptase - An amino acid not found in proteins is
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a) Homocysteine
b) Proline
c) Lysine
d) Histidine - Following are the beneficial effect of Reactive Oxygen Species (ROS) expect
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a) Bactericidal effect
b) Reduces blood pressure
c) Radiotherapy
d) Mutations - The most abundant protein in mammals is
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a) Albumin
b) Globulin
c) Collagen
d) Histatin - Which of the following is not a biologically important peptide?
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a) Glutathione
b) Angiotensin
c) Vasopressin
d) Leukotriene - Which one of the following enzyme acts as a biomarker in the diagnosis of prostate cancer?
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a) Amylase
b) AST
c) Acid phosphatase
d) Alkaline phosphatase
Essay/ Long Answer Questions: 2x15=30
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- A 16-year-old boy who was given blood transfusion recently had presented with chills and rigors of 2 days duration. Laboratory investigations revealed the following findings:
Serum total bilirubin: 4.8 mg/dl, Serum conjugated bilirubin: 0.2 mg/dL,
Urine Bilirubin: Negative, Van den Bergh reaction is indirect positive.
a) What is the probable diagnosis?
b) How do you relate the history and laboratory findings to confirm your diagnosis? (Use a flow chart to explain if required)--- Content provided by FirstRanker.com ---
c) Describe normal bilirubin metabolism.
d) Name the test performed to identify presence of bile pigments in the urine.
(1+4+8+2) - Explain the structure of DNA under the following headings:
a) Using a neat a labelled diagram explains the structural organization of DNA.--- Content provided by FirstRanker.com ---
b) Name the histone proteins.
c) Compare and contrast the differences between DNA and RNA.
d) Name the different forms of DNA.
(8+2+3+2)
Short Answer Questions: 7x6=42
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- Name the different levels of the structural organization of proteins. Discuss the secondary structure of proteins and add a note on the bonds responsible for stabilizing the secondary structure.
- Write the compounds derived from glycine and their importance
- Explain how learning influences the Physician Growth
- What are tumor markers? Discuss the clinical utility of any three tumor markers.
- Describe in detail the glomerular function tests. Add a note on the formulae available for calculating estimated glomerular filtration rate (eGFR).
- Describe the structure of the haemoglobin molecule. Add a note on Thalassemia.
- Explain with diagram the structure of IgG molecule and indicate its binding sites and function of IgG.
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Very Short Answer Questions: 6x3=18
- Name the plasma proteins. Write the functions of serum albumin.
- Operon Concept
- Name the thyroid function tests. Write the reference range for T4 and TSH.
- Post translational modifications.
- Phase I detoxification reactions.
- Alkali reserve.
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