QP. CODE: MB2019101
KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE-506 002
MBBS FIRST YEAR EXAMINATIONS: FEBRUARY, 2023
BIOCHEMISTRY PAPER I
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Time: 3 Hours Max Marks: 100
Note: Answer all questions.
Give Diagrammatic representation whenever necessary
Write an essay on the following: 2x15=30
- A 45-year-old man is brought to the hospital in a comatose state on examination. He was found to be dehydrated and toxic with a characteristic breathing pattern and a sweet smell on his breath. He is admitted to the ward and investigated the following are the results of the lab investigations. RBS-380 mg%, Benedict's test with urine-positive brick red. Rothera's test with urine-positive. Plasma pH-7.35, Serum HCO3-15 meq/L
- Write the probable diagnosis (1+3+5+6)
- How do you interpret the above laboratory data?
- Discuss the pathophysiology of this case.
- What are the enzymes influenced by insulin? What are the derangements seen in diabetes mellitus?
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- Enumerate the major steps of synthesis of cholesterol. (7+1+2+5)
- Name the rate limiting step of cholesterol synthesis.
- Explain how the cholesterol is transported from liver to peripheral tissues and back.
- Describe the role of cholesterol in atherosclerosis.
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Write a short note on the following: 8x5=40
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- Sickle cell disease.
- Name the renal clearance tests. Give details of any one of them.
- Phenylketonuria.
- Write about the tumour markers. Add a note about telomeres.
- Explain principle, procedure and applications of polymerase chain reaction (PCR)
- Thyroid function tests.
- Porphyrias.
- What are restriction enzymes? Explain by giving examples. What are their uses?
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Write briefly on the following: 10X3=30
- Alkaptonuria.
- Polyamines.
- Anti Diuretic hormone (ADH)
- DNA mutations.
- Mention the types of DNA mutations.
- Justify the statement: "defects in DNA repair mechanisms leads to cancer"
- Biologically active peptides.
- Vandenberg Reaction.
- Orotic Aciduria.
- What is a Codon? Describe the salient features of genetic code.
- Anion Gap.
- Urinary Vanillyl Mandelic Acid (VMA) estimation is helpful for the diagnosis of Phaeocromocytoma - Justify.
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