Download KNRUHS 2nd Year MBBS 2024 February MB2019111 Pharmacology Paper I Question Paper

PAPER CODE: MB2019111

KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES

WARANGAL, TELANGANA STATE - 506002

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MBBS SECOND YEAR DEGREE EXAMINATION FEBRUARY, 2024

PHARMACOLOGY PAPER-I

Time: 3 Hours

Note: Answer all questions.

Give Diagrammatic representation wherever necessary.

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Max Marks: 100

Multiple Choice Questions: 10 X 1=10

1. The drug which acts by inhibiting an enzyme in the body is:
   1. Atropine
   2. Allopurinol
   3. Levodopa

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   4. Metoclopramide
2. Which of the following drug produce tachyphylaxis?
   1. Adrenaline
   2. Ephedrine
   3. Dopamine

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   4. Isoprenaline
3. The antidote of choice for morphine poisoning is:
   1. Nalorphine
   2. Nalbuphine
   3. Naltrexone

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   4. Naloxone
4. Histamine is involved as a mediator in the following pathological condition:
   1. Delayed hypersensitivity
   2. Inflammation
   3. Carcinoid syndrome

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   4. Variant angina
5. The following analgesic lacks anti-inflammatory action:
   1. Paracetamol
   2. Ibuprofen
   3. Diclofenac sodium

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   4. Piroxicam
6. Acetylcysteine is used in the following condition
   1. Carbon Monoxide Poisoning
   2. OP Poisoning
   3. Paracetamol Poisoning

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   4. Salbutamol Poisoning
7. A 20-year-old woman is taking over-the-counter diphenhydramine for severe hay fever. Which of the following adverse effects is she most likely to report?
   1. Diarrhoea
   2. Sedation
   3. Nervousness, anxiety

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   4. Vertigo
8. Which of the following is not a prodrug
   1. Levodopa
   2. Enalapril
   3. Dipivefrine

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   4. Amoxicillin
9. Cholinomimetic drugs can be used for the treatment of all of the following conditions except
   1. Bradycardia
   2. Closed angle glaucoma
   3. Cobra bite

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   4. Myasthenia gravis
10. Bisacodyl is
    1. bulk forming purgative
    2. stimulant purgative

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Essay/Long Answer Questions: 5X4=20

11. a) Define Bioavailability. Describe any five factors affecting drug bioavailability. (2+5)
    b) Define Prodrug. Describe the clinical significance of prodrugs with suitable examples. (2+6)
12. Classify Antiepileptic Drugs. Describe the mechanism of action, therapeutic uses and adverse effects of Phenytoin. (6+3+3+3)

Short Answer Questions: 7 X 6 = 42

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13. Describe pharmacotherapy of Prophylaxis of Migraine.
14. Compare and contrast Physostigmine and Neostigmine.
15. Explain the drug antagonism with examples.
16. Mention five drugs used in pre-anaesthetic medication with their rationale.
17. Describe therapeutic uses and adverse effects of Beta Blockers.

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18. Discuss the pharmacological management of Acute Severe Asthma.
19. Describe how to motivate patients with long standing Type II diabetes to adhere to the prescribed treatment of the physician.

Very Short Answer Questions: 6 X 3 = 18

20. Write the rationale of combining Adrenaline with Lignocaine.
21. Rationale of using ethanol in Methanol Poisoning.

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22. Enlist the non- Diarrhoeal uses of Oral Rehydration solution.
23. Therapeutic uses of centrally acting Skeletal Muscle Relaxants.
24. Mention advantages of Second-Generation Antihistamines over Conventional Antihistamines.
25. Clinical significance of Plasma Protein binding with examples.

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