Download KNRUHS 2nd Year MBBS 2024 February MB2019113 Pathology Paper I Question Paper

Time: 3 Hours

Max Marks: 100

Note: Answer all questions.
Give Diagrammatic representation wherever necessary.

Multiple Choice Questions: 10 X 1=10

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1. Morphologic changes seen in chronic non-specific inflammation include an increase in:
   1. Neutrophils, lymphocytes and liquefaction necrosis
   2. Neutrophils, macrophages and fibrosis
   3. Lymphocytes, plasma cells and fibrosis
   4. Giant cells, macrophages and coagulative necrosis

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2. CREST Syndrome include all of the following except?
   1. Conjunctivitis
   2. Calcinosis
   3. Telangiectasia
   4. Sclerodactyly

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3. Secondary amyloidosis is observed in all EXCEPT:
   1. Bronchiectasis
   2. Chronic osteomyelitis
   3. Crohn's disease
   4. Carcinoid appendix

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4. Grading of cancer is based on which of the following statement:
   1. Size of the primary tumor
   2. Spread of cancer cells to regional lymph nodes
   3. Presence of blood born metastasis
   4. Degree of differentiation of tumor cells and anaplasia

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5. The chemical carcinogen, aflatoxin B-1 (food contaminant) derived from a fungus, which causes
   1. Transitional cell carcinoma of lung
   2. Adenocarcinoma of rectum
   3. Squamous cell carcinoma of skin
   4. Hepatocellular carcinoma

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6. Secondary tuberculosis manifests in the following ways EXCEPT:
   1. Fibro-caseous lesions
   2. Miliary tuberculosis
   3. Ghon's complex
   4. Tuberculous pneumonia

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7. In primary tuberculosis, all of the following may be seen EXCEPT:
   1. Granulomas
   2. Caseation
   3. Cavitation
   4. Calcification

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8. Which of the following is NOT transmitted through mosquito bite?
   1. Malaria
   2. Kala-azar
   3. Japanese encephalitis
   4. Dengue Fever

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9. Which is NOT a sex linked disease:
   1. Haemophilia A
   2. G-6-PD deficiency
   3. Cystic fibrosis of Pancreas
   4. Color blindness

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10. In foetal life, RBC's are formed in?
    1. Spleen and Liver
    2. Bone marrow
    3. Kidney and lungs
    4. Pancreas

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Essay/Long Answer Questions: 2X15=30

11. Classify Shock. Describe the pathology of Septic Shock.
12. Classify Haemolytic Anaemia. Discuss the pathogenesis of Sickle Cell Anaemia.

Short Answer Questions: 7 X 6 = 42

13. Discuss pathology and morphology of Fatty Change.

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14. Describe Coombs test and its significance.
15. Define Paraneoplastic Syndromes and give examples.
16. Discuss pathogenesis of Amyloidosis.
17. Prothrombin time and its clinical utility.
18. Pathological Calcification.

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19. Neuroblastoma.

Very Short Answer Questions: 6 X 3 = 18

20. Define metaplasia with examples.
21. Auto Antibodies in systemic Lupus Erythematosus.
22. Bombay Blood Group.

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23. Ghon's Complex.
24. Define Leukemoid Reaction with causes.
25. Philadelphia Chromosome.