QP CODE: 1028
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Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase - II (CBME) Degree Examination - 06-Dec-2024
Time: Three Hours Max. Marks: 100
PHARMACOLOGY – PAPER I (RS-4)
Q.P. CODE: 1028
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(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks
- Define Bioavailability. Discuss the factors affecting bioavailability of a drug administered orally.
- A forty-five-year-old farmer was brought to the hospital with breathlessness, lacrimation, bowel and bladder incontinence. A diagnosis of Organophosphorous poisoning was made.
- Outline the management of this patient.
- Mention the specific antidotes useful in this patient and explain the rationale of using them
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SHORT ESSAYS 8 x 5 = 40 Marks
- What is microsomal enzyme induction? Explain its consequences with any two examples
- Mention any three Atropine substitutes and explain their therapeutic uses
- Write the mechanism of action and therapeutic uses of Benzodiazepines
- Write the mechanism of action, adverse effects and therapeutic uses of Sodium Valproate
- Discuss the various techniques of local anaesthesia
- A 25-year-old computer engineer presents with episodes of unilateral pulsatile headache preceded by photophobia and vomiting for the past few months. A diagnosis of Migraine was made. She was prescribed Sumatriptan. Explain the mechanism of action and contraindications for Triptans
- A 52-year-old lady, a known asthmatic presents to the hospital with acute breathlessness and wheeze. A diagnosis of Status asthmaticus (Acute severe asthma) was made. Discuss the pharmacotherapy of Status asthmaticus (Acute severe asthma)
- Write the mechanism of action and therapeutic uses of Omeprazole
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SHORT ANSWERS 10 x 3 = 30 Marks
- What is Teratogenicity? Mention two drugs causing teratogenicity with their teratogenic effects
- List three classes of drugs with a suitable example for each used in Chronic simple (open angle) Glaucoma
- Write three advantages of Selective serotonin reuptake inhibitors over Tricyclic antidepressants
- Write the rationale of using Morphine in acute left ventricular failure
- Aspirin causes gastric mucosal damage. Explain
- Name three Antitussives
- Rationale of using Ondansetron in cancer chemotherapy induced vomiting
- Mention three advantages of Halothane as general anaesthetic agent
- Name three drugs obtained from plant sources
- List three uses of Dimercaprol
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Multiple Choice Questions 10 x 1 = 10 Marks
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- i) The therapeutic index of a drug indicates its
- Safety
- Efficacy
- Potency
- All of the above
- ii) Which of the following drug undergoes Hofmann elimination?
- Atracurium
- Pancuronium
- Vecuronium
- Rocuronium
- iii) The mydriatic with quickest and briefest action is
- Atropine
- Homatropine
- Cyclopentolate
- Tropicamide
- iv) Ethanol is administered in methanol poisoning to
- Correct acidosis caused by formic acid
- Prevent seizures due to methanol
- Compete with methanol for alcohol dehydrogenase
- Increase generation of formaldehyde
- v) The agent which can reverse the sedative action of Benzodiazepines is
- Caffeine
- Doxapram
- Acetyl cysteine
- Flumazenil
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- i) The standard drug therapy for Parkinson's disease is
- Pyridoxine
- Dopamine
- Levodopa + Carbidopa
- Dopamine + Pyridoxine
- ii) The prostaglandin analogue used in Peptic ulcer disease is
- Misoprostol
- Carboprost
- Latanoprost
- Travoprost
- iii) The class of drug NOT used in the treatment of bronchial asthma is
- Beta agonists
- Corticosteroids
- Methylxanthines
- Cholinesterase inhibitors
- iv) Oral rehydration therapy has one of the following beneficial effects
- Stops diarrhoea
- Restores hydration and electrolyte balance
- Hastens the clearance of enteropathogens
- Avoids the need for specific antimicrobial therapy
- v) Drug used in treatment of scorpion sting is
- Pralidoxime
- Pramipexole
- Prazosin
- Propylthiouracil
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