PTU B-Pharma 2nd Semester May 2019 46213 PHARMACEUTICAL CHEMISTRY III Organic Chemistry Question Paper

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Total No. of Pages : 02

Total No. of Questions : 10

B.Pharma (2011 to 2016) (Sem.-2)

PHARMACEUTICAL CHEMISTRY-III (Organic Chemistry)

Subject Code : BPHM-203

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M.Code: 46213

Time: 3 Hrs.

Max. Marks : 80

INSTRUCTION TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of FIFTEEN questions carrying TWO marks each.

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2. SECTION-B contains FIVE questions carrying FIVE marks each and students have to attempt any FOUR questions.
3. SECTION-C contains FOUR questions carrying TEN marks each and students have to attempt any THREE questions.

SECTION-A

1. Answer briefly :
   1. Bonding orbitals
   2. Debye

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   3. sp³ hybridization in ammonia
   4. Soft acid
   5. Intramolecular hydrogen bond
   6. Secondary bonding
   7. Enantiomerism.

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   8. Resolution of racemic mixture
   9. Optical inactivity in meso compounds
   10. Geometry of carbanion ion
   11. Bimolecular elimination reactions
   12. Crown ethers

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   13. Acidity constant of acids
   14. Mixed acid used for nitration of Benzene
   15. Acidity of picric acid

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SECTION-B

2. Explain concept stereoselectivity and stereospecificity with example of each.
3. Explain any two reactions involving carbene reaction intermediate.
4. Compare stereochemical aspect of SN1 and SN2 reactions in alkyl halide.
5. Give two postulates of Baeyer's strain theory. What are its limitations?

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6. Explain the mechanism of electrophilic addition of hydrogen halide to unsymmetrically substituted alkenes.

SECTION-C

7. a) Describe the preparation of alcohol by oxymercuration-demercuration of alkenes.
   b) Williamson synthesis of ether is nucleophilic substitution reaction. Justify.
8. a) Explain the mechanism of Freidal Craft alkylation in Benzene.
   

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   b) Explain the mechanism of nucleophilic addition in aldehyde by citing example of Aldol condensation.
9. a) Describe electrophilic substitution in naphthalene.
   b) Compare acidity of benzoic acid and phenol.
10. Write chemical reactions for
    1. Sulfonation of benzene
    2. Formation of acid by hydrolysis of nitrile.

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    3. Conversion of acid to acid chloride.
    4. Formation of diazonium salt.
    5. Formation of sodium salicylate from sodium phenoxide.

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.

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