PTU B-Pharma 2nd Semester May 2019 74969 BIOCHEMISTRY Question Paper

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Total No. of Pages : 03

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Roll No.

Total No. of Questions: 13

B.Pharma (2017 & Onwards) (Sem.-2)

BIOCHEMISTRY

Subject Code : BP-203T

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M.Code: 74969

Time: 3 Hrs.

Max. Marks: 75

INSTRUCTIONS TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of TEN questions carrying TWO marks each.

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2. SECTION-B contains THREE questions carrying TEN marks each and student has to attempt any TWO questions.
3. SECTION-C contains NINE questions carrying FIVE marks each and student has to attempt any SEVEN questions.

SECTION-A

Q1. Answer briefly :

1. Amino acid residues present in protein
   1. a

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   2. ß
   4. d
   are __________ amino acids.
2. Formation of cyclic structure of glucose from open chain structure is an example of..........
   1. Nucleophilic addition
   2. Formation of hemi-acetal

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   4. i and ii
3. Sphingomylein is a derivative of
   1. Sphingosine
   2. Ceramide
   3. Phosphotidic acid

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   4. i and ii.
4. For Ca-C bond in backbone of protein, the bond angle resulting from rotation at Ca is labeled as
   1. F
   2. Y
   3. ?

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   4. i and ii both
5. The successive nucleotides in DNA are linked through ............ bridge.
   1. Phosphodiester
   2. Amide
   3. Glycosidic

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   4. ACP
6. __________ transports free fatty acid from cytosol to mitochondria.
   1. Carnitine shuttle
   2. Citrate shuttle
   3. Both i and ii

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   4. Neither i nor ii
7. ATP is
   1. Nucleotide
   2. Energy link between anabolism and catabolism
   3. Hydrolysed with positive AG

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   4. All of the above
8. __________ is an essential amino acid.
   1. Lysine
   3. Glycine
   4. Alanine.

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9. Transfer of amino acid acid to a keto acid is known as
   1. Transamination
   2. Deamination
   3. Transdeamination
   4. i and iii both.

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10. Myocardial infarction can be diagnosed by isoenzyme of
    1. LDH
    2. ALP
    3. SGOT
    4. None of these

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SECTION-B

Q2 Give outline for gluconeogenesis. Explain its biochemical significance.

Q3 Describe the de novo synthesis of pyrimidine nucleotides. Comment on hyperuricemia.

Q4 Give IUB system of enzyme classification. Discuss the two diagnostic applications of isoenzymes citing suitable examples.

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SECTION-C

Q5 Explain various types of stereoisomerism present in monosaccharides.

Q6 Explain the mechanism of oxidative phosphorylation.

Q7 Describe the various steps involved in ß-oxidation.

Q8 Describe biosynthesis of catecholamines from tyrosine catabolism.

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Q9 Discuss the biochemical causes of jaundice.

Q10 Describe reactions of Kreb-Henseleit cycle.

Q11 Describe post transcriptional modifications in primary transcripts of mRNA.

Q12 Give outline for the conversion of cholesterol to adrenal cortex hormone.

Q13 Give structure and biochemical significance of co-enzymes derived from Vitamin B2.

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NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.

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