PTU B-Pharma 4th Semester May 2019 46232 PHARMACEUTICAL ANALYSIS II Question Paper

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Total No. of Pages : 02

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Roll No. :

Total No. of Questions : 10

B.Pharma (2011 to 2016) (Sem.-4)

PHARMACEUTICAL ANALYSIS-II

Subject Code : BPHM-402

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M.Code : 46232

Time: 3 Hrs. Max. Marks : 80

INSTRUCTION TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of FIFTEEN questions carrying TWO marks each.
2. SECTION-B contains FIVE questions carrying FIVE marks each and students have to attempt any FOUR questions.

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3. SECTION-C contains FOUR questions carrying TEN marks each and students have to attempt any THREE questions.

SECTION-A

Q1. Explain in brief :

1. Define Werner's coordination number with examples.
2. What type of drugs are analysed by non-aqueous titrations? Give two examples.

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3. Give composition of Karl-Fischer's reagent.
4. Define partition coefficient.
5. Give two examples of radiopaque media and their applications.
6. What chromatographic technique is most commonly used for purification of amino acids? Justify with reason.
7. What do you understand by HETP? How does it affect resolution?

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8. Give two major limitations of gas chromatography.
9. How do you express SHE connected to a copper half cell composed of Cu wire in 1M CuS04 solution?
10. Name any two techniques used to locate equivalence point in an acid base titration.
11. What is specific conductance?
12. Define limiting current. What is its significance?

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13. How pH affects extraction?
14. What is void volume of a HPLC column? How is it related to separation efficiency?
15. How would you analyse sulfacetamide by titrimetric analysis?

SECTION-B

Q2 What is the principle of conductometric methods of analysis? Discuss the construction and working of a conductivity cell.

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Q3 Explain the concept of masking and demasking in complexometric titrations with examples. Give an application.

Q4 Write an explanatory note on Kjeldahl nitrogen determination.

Q5 How an isotope differs from a radioisotope? Give examples. Explain their applications in pharmacy.

Q6 What is the principle of ion-exchange chromatography? Write an account on various ion-exchange based stationary phases and their applications.

SECTION-C

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Q7 What is the principle of liquid-liquid chromatography? Write a detailed account on various stationary phases used in it with emphasis on their chemistry, applications and limitations.

Q8 Explain the different components of instrumentation of GLC with the help of neat diagrams.

Q9 How do you prepare 0.1 M solution of HClO4? Give principle, chemical equations involved, procedure and general calculations for its standardization and one application.

Q10 What is the principle of polarographic analysis. Discuss various factors affecting it. Explain the construction and working a dropping mercury electrode with the help of a neat diagram.

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.

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