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Roll No.
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Total No. of Pages : 02
Total No. of Questions : 10
B.Pharma (2011 to 2016) (Sem.-8)
PHARMACEUTICAL CHEMISTRY – VIII
(MEDICINAL CHEMISTRY – III)
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Subject Code : BPHM-805
M.Code: 72300
Time: 3 Hrs.
Max. Marks : 80
INSTRUCTIONS TO CANDIDATES :
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- SECTION-A is COMPULSORY consisting of FIFTEEN questions carrying TWO marks each.
- SECTION-B contains FIVE questions carrying FIVE marks each and students have to attempt any FOUR questions.
- SECTION-C contains FOUR questions carrying TEN marks each and students have to attempt any THREE questions.
SECTION-A
I. Give structure, IUPAC name and one specific use of following drugs :
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- Isoniazid
- Methicillin.
- Proguanil
- Ornidazole
- Mebendazole
- Fluconazole
- Abacavir
- Docetaxel
- Temoxifen
- Methimazole
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II. Attempt the following :
- What is biotransformation?
- Draw structures of two drugs that undergoes sulphonation by glutathione-S-transferase?
- What are meglitinides?
- Draw structures of T4 and T3 thyroid hormones?
- Draw the structures of two aminopyrimidine derivatives used in combination therapy with sulphonamide.
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SECTION-B
2. Discuss SAR of 4-aminoquinolines for anti-malarial activity.
3. What are anthelmintics? Give synthesis of Nicolsamide.
4. Draw structures of imidazole derivatives used for treatment of fungal infection. Give synthesis of any one of them.
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5. Give an account of antithyroid drugs.
6. Give structures and mechanism of action of purine analogues used as antiviral agents.
SECTION-C
7. Describe various types of reactions involved in phase I of drug metabolism citing suitable example of each.
8. a) Discuss the SAR of thyroid hormones.
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b) Discuss structure of insulin.
9. Classify antineoplastic drugs with two structural examples of each class. Give synthesis of chlorambucil.
10. What are (B-lactam antibiotics? Describe various classes of penicillins.
NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.
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This download link is referred from the post: PTU B.Pharma 8th Semester Last 10 Years 2011-2021 Previous Question Papers|| Punjab Technical University
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