Max. Marks: 80 Marks
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MEDICINAL CHEMISTRY - I
(Revised Scheme - 2)
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Q.P. CODE: 1961Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
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LONG ESSAYS (Answer any Two)
2 x 10 = 20 Marks
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1.Explain how the solubility, Hydrogen bonding, protein binding and surface activity influence
on the biological activity.
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2.
Define and classify hypnotics and sedative with examples. Explain the SAR of
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benzodiazepine derivatives. Outline the Synthesis of Diazepam and Chlordiazepoxide.3.
Classify Antihistaminic agents with examples. Outline the method for synthesis of
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Diphenhydramine Hydrochloride and Promethazine.
SHORT ESSAYS (Answer any Eight)
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8 x 5 = 40 Marks4.
Explain the role of P-450 cytochrome mono-oxygenase in oxidative biotransformations.
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5.
Define and classify General Anaesthetics with suitable examples.
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6.What are Ganglionic blocking agents? Give examples with their uses.
7.
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Classify NSAID with examples. Write the Synthetic step of mefenamic acid.
8.
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Write the structure and uses of any four -Adrenergic Blocking Agents.9.
Write a note on reversible cholinesterase inhibitors.
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10.
Define and classify local anaesthetics with examples.
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11.Write the structures and uses of any four prostaglandins.
12.
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What are Cholinergic blocking agents? Classify them with suitable examples. Write the
Synthesis of dicyclomine.
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13.What is Epilepsy? Write the synthesis and uses of carbamazepine.
SHORT ANSWERS
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10 x 2 = 20 Marks
14.
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Write any two structure and uses Narcotic Analgesics.15.
Drugs used in spasticity
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16.
Outline the Synthesis of Propranolol
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17.H2 receptor antagonists
18.
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Write structure and uses of any two antitussive agents.
19.
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Skeletal muscale relaxants20.
Name any two -receptor Agonists and give their structures.
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21.
Write the structure and uses of phenytoin sodium and Clonazepam.
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22.Dissociative anaesthetics
23.
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What are Neuromuscular blocking agents give examples.
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