Max. Marks: 70 Marks
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MEDICINAL CHEMISTRY - I
(Revised Scheme 3)
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Q.P. CODE: 2611Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary. Answer all questions
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LONG ESSAYS (Answer any Two)
2 x 10 = 20 Marks
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1.What are general anesthetics? Classify them with examples. Add a note on ultra short acting
barbiturates & dissociative anaesthetics.
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2.What are sympathomimetic agents and discuss their classification and SAR. Give the synthesis
of Naphazoline.
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3.Define Antihistamines, classify them with examples. Discuss their SAR and give the synthesis
of promethazine.
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SHORT ESSAYS (Answer any Six)6 x 5 = 30 Marks
4.
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Explain phase I drug metabolism with examples.
5.
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Explain the structural activity relationship of benzoic acid derivatives as local anesthetics.6.
What are anticonvulsants, classify them with examples, outline the synthesis of
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carbamazepine.7.
Classify cholinergic blocking agents with examples. Give the synthesis of Dicyclomine.
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8.
What are adrenergic blocking agents classify and write the synthesis of phentolamine.
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9.Write the Bio synthetic pathway of eicosanoids.
10.
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Discuss the SAR of Benzodiazepines.
11.
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Discuss the role of hydrogen bonding in drug design.SHORT ANSWERS
10 x 2 = 20 Marks
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12.
Drug used in spasticity.
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13.H 2receptors antagonists.
14.
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Factors effecting drug metabolism
15.
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Clinically useful prostaglandins.16.
Skeletal muscle relaxants.
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17.
Synthesis of Oxyphenbutazone.
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18.Synthesis of Phenobarbitone.
19.
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Structure and uses of Codeine and Nalorphine.
20.
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Structure and uses of Noscapine and Chlordiazepoxide.21.
Name the conjugation reactions involved in Phase-II metabolism.
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