Max. Marks: 70 Marks
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MEDICINAL CHEMISTRY - I
(RS - 4)
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Q.P. CODE: 2635Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary. Answer all questions
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LONG ESSAYS (Answer any Two)
2 x 10 = 20 Marks
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1.Write a note on Cytochrome P-450 and monoaminooxygenase with specific emphasis on its
constitution and their role in biotransformation.
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2.Define sedative and hypnotics. Explain the SAR of barbiturates. Write the synthesis of barbital.
3.
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a) Write a note on drug receptor interactions.
b) Write a note on skeletal muscle relaxants.
SHORT ESSAYS (Answer any Six)
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6 x 5 = 30 Marks
4.
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Outline the synthesis and uses of propranolol and clonidine5.
Give the structure and therapeutic significance of any two irreversible cholinesterase inhibitors.
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6.
Define and classify local anaesthetic agents with examples. Outline the synthesis of procaine
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7.Explain in detail about histamine receptors.
8.
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What are narcotic analgesics? Write the structure and uses of any four drugs.
9.
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Enumerate the structural elucidation of ephedrine.10.
Outline the synthesis of Diazepam and Glutethimide
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11.
Explain the importance of partition co-efficient in the biological activity.
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SHORT ANSWERS10 x 2 = 20 Marks
12.
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Define the terms "hit" and "lead" in drug design
13.
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What are inhalation anaesthetics? Give examples14.
Define spasticity. Mention two antispastic drugs.
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15.
Outline the synthesis of isoproterenol
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16.Write the structure and uses of any two cholinergic blocking agents
17.
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Write the structure and uses of trimethophan and mecamylamine
18.
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Write the synthesis of cetrizine19.
What are narcotic antagonists?
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20.
Write the structure of aspirin. Give its various medicinal uses.
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21.What are prostaglandins? Give examples.
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