Download RGUHS B.Pharm 2018 January 3rd Year 2635 Medicinal Chemistry I Rs 4 Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) B.Pharm (Bachelor of Pharmacy) 2018 January 3rd Year 2635 Medicinal Chemistry I Rs 4 Previous Question Paper


Rajiv Gandhi University of Health Sciences, Karnataka

III Year B.Pharm Degree Examination ? DEC-2018

Time: Three Hours



Max. Marks: 70 Marks

MEDICINAL CHEMISTRY - I

(RS - 4)

Q.P. CODE: 2635

Your answers should be specific to the questions asked

Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAYS (Answer any Two)

2 x 10 = 20 Marks

1.

Write a note on Cytochrome P-450 and monoaminooxygenase with specific emphasis on its
constitution and their role in biotransformation.

2.

Define sedative and hypnotics. Explain the SAR of barbiturates. Write the synthesis of barbital.

3.

a) Write a note on drug receptor interactions.
b) Write a note on skeletal muscle relaxants.

SHORT ESSAYS (Answer any Six)

6 x 5 = 30 Marks

4.

Outline the synthesis and uses of propranolol and clonidine

5.

Give the structure and therapeutic significance of any two irreversible cholinesterase inhibitors.

6.

Define and classify local anaesthetic agents with examples. Outline the synthesis of procaine

7.

Explain in detail about histamine receptors.

8.

What are narcotic analgesics? Write the structure and uses of any four drugs.

9.

Enumerate the structural elucidation of ephedrine.

10.

Outline the synthesis of Diazepam and Glutethimide

11.

Explain the importance of partition co-efficient in the biological activity.

SHORT ANSWERS

10 x 2 = 20 Marks

12.

Define the terms "hit" and "lead" in drug design

13.

What are inhalation anaesthetics? Give examples

14.

Define spasticity. Mention two antispastic drugs.

15.

Outline the synthesis of isoproterenol

16.

Write the structure and uses of any two cholinergic blocking agents

17.

Write the structure and uses of trimethophan and mecamylamine

18.

Write the synthesis of cetrizine

19.

What are narcotic antagonists?

20.

Write the structure of aspirin. Give its various medicinal uses.

21.

What are prostaglandins? Give examples.

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This post was last modified on 06 January 2023