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2106000102010101-S
EXAMINATION MARCH-APRIL 2024
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BACHELOR OF MEDICINE AND
BACHELOR OF SURGERY (SECOND YEAR)
PATHOLOGY (PAPER - I) - LEVEL 1 OMR
[Time: As Per Schedule] [Max. Marks: 100]
Instructions:
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- Fill up strictly the following details on your answer book
- Name of the Examination : BACHELOR OF MEDICINE AND BACHELOR OF SURGERY (SECOND YEAR)
- Name of the Subject : PATHOLOGY (PAPER - 1) - LEVEL 1 OMR
- Subject Code No : 2106000102010101-S
- Sketch neat and labelled diagram wherever necessary.
- Figures to the right indicate full marks of the question.
- All questions are compulsory.
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Seat No: |
Student's Signature |
SECTION-I
Q.1 Multiple Choice Questions. (Instruction: Encircle the correct answer:) 20
- The main cell in chronic inflammation:
- B-lymphocyte
- Plasma cell
- Macrophage
- Fibroblast
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- Bilateral hilar lymphadenopathy showing Non caseating granulomas is most characteristic of:
- Tuberculosis
- Sarcoidosis
- Systemic Lupus Erythematosus
- Leprosy
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- Earliest event in acute inflammation is :
- Vasodilatation
- RBC Rouleaux formation
- Increased vascular permeability
- Margination
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- The most specific stain for demonstration of amyloid is :
- Methyl violet with metachromasia
- PAS stain
- Thioflavin S under fluorescence
- Congo red with examination in polarized light
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- Apoptosis is :
- Cell death due to exogenous stimuli
- Due to activation of internally controlled programme
- Necrosis associated with putrefaction
- Subcellular level changes without any morphologic alterations.
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- In granuloma, epithelioid and giant cells are derived from:
- T lymphocytes
- Mast cells
- B lymphocytes
- Monocyte-macrophages
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- HLA B 27 is associated with increased risk of development of:
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Reiter's Syndrome
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- Bence Jones Proteins are :
- Light chains of immunoglobulins
- Heavy chains of immunoglobulin
- Fc portion of immunoglobulin
- Microglobulin
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- Type of hypersensitivity reaction in Erythroblastosis Fetalis:
- Type I
- Type II
- Type III
- Type IV
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- Oedema in Nephrotic Syndrome is due to :
- Increased hydrostatic Pressure
- Decreased Plasma Osmotic Pressure
- Lymphatic Obstruction
- Increased Plasma Osmotic Pressure
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- What minimum percentage of sudden loss of blood volume causes death:
- 20%
- 50%
- 33%
- 75%
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- What is FALSE about Lyon Hypothesis?
- Only one X chromosome is genetically active
- There is random inactivation of other chromosome
- Inactive X chromosome is seen as Barr body
- Barr bodies are easily demonstrated in any epithelial cells.
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- Gaucher's disease is caused by deficiency of:
- Hexosaminades
- Sphingomylelinase
- Pyruvate Kinase
- Glucocerebrosidase
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- Replacement of one adult cell type by another cell type is called:
- Metaplasia
- Hyperplasia
- Anaplasia
- Dysplasia
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- Bombay Phenotype are the individuals who:
- Lack of H genes and therefore H substance.
- Possess A and B antigen
- Secrete excessive amount of H substance
- Lack C,D,E antigens
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- Osteogenic sarcoma of femur usually metastasizes to:
- Inguinal lymphnodes
- Liver
- Lungs
- Paraaortic lymphnode
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- Amyloidosis in long term hemodialysis is due to:
- Transthyretin
- ß2 Microglobulin
- Amyloid associated protein
- ß Amyloid protein
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- All are cardinal signs of inflammation except :
- Pain
- Redness
- Swelling
- Cyanosis
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- Oliguria implies 24 hrs urine output less than:
- 200ml
- 400ml
- 600ml
- 800ml
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- "Tombstone" appearance of cells is seen in which type of Necrosis?
- Fibrinoid
- Coagulative
- Liquefactive
- Fat
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SECTION-II 40
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Q.2 Case based question (compulsory to attempt) 13
20 yrs female presented with fatigue, rashes on bridge of nose and both cheeks, joint pain and blood picture showed pancytopenia,
- What is the probable diagnosis? 1
- Describe the etiopathogenesis of the disease. 4
- Describe the first lab diagnostic test which was done earlier in patients Diagnosed with this disease. 3
- Write the immunofluorescence patterns seen in blood of such patient. 1
- Describe the morphology of major lesions seen in this disease. 4
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Q.3 Long Essay Questions (Attempt any 3 out of 4) (9 Marks Each) 27
- Define Metastasis. Write three different routes of Metastasis. Describe Cell biology of Invasion and Metastasis Cascade. 1+3+5
- Describe various types of Cellular and plasma Blood components prepared from whole blood. Mention clinical use of each blood component. 5+4
- Describe the Vascular and cellular events of acute inflammatory response. 5+4
- Enumerate urine and blood investigations in diagnosis of Diabetes. 3+6
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SECTION-III 40
Q.4 (Attempt any 8 out of 10) (5 marks Each)
- Define Neoplasia. Difference between benign and malignant tumour.
- Describe clinical features and underlying cytogenetic abnormalities of klinefelter's Syndrome.
- Describe the etiopathogenesis of intracellular accumulation of Neutral fat in Liver.
- Describe Free radical mediated cell injury.
- Define Necrosis. Describe types of necrosis with their morphology.
- Describe the structure of HIV Virus. enumerate the genes that code for Respective viral proteins.
- Define Hypersensitivity. Describe the pathogenesis of Type I hypersensitivity reaction with 2 examples.
- Difference between Kwashiorkor and Marasmus.
- Difference between Transudate and Exudate.
- Describe the Mechanism and effects of three stages of Shock.
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