Download VNSGU MBBS 2106000102020101 Pharmacology Paper I April 2024 OMR Question Paper

FirstRanker.com

2106000102020101-S

EXAMINATION MARCH-APRIL 2024

--- Content provided by⁠ FirstRanker.com ---

BACHELOR OF MEDICINE AND BACHELOR OF SURGERY (SECOND YEAR)

PHARMACOLOGY (PAPER - I ) - LEVEL 2 OMR

[Time: As Per Schedule] [Max. Marks:100]

Section I

Q.1 Multiple choice questions (MCQs) 1*20=20

Instructions:

1. Encircle the most appropriate answer.

--- Content provided by‍ FirstRanker.com ---

2. Each question carries one mark and there is no negative marking.
3. Overwriting is not allowed.

1. Acidic drugs bind to:
   1. Albumin
   2. ß Globulin
   3. Enzyme

   --- Content provided by‌ FirstRanker.com ---

   4. Receptor
2. A highly ionized drug:
   1. Is excreted mainly by the kidney
   2. Can cross the placental barrier easily
   3. Is well absorbed from the intestine

   --- Content provided by‌ FirstRanker.com ---

   4. Accumulates in the cellular lipids
3. At toxic doses, zero order kinetics is seen in:
   1. Penicillin
   2. Phenytoin
   3. Valproate

   --- Content provided by⁠ FirstRanker.com ---

   4. Carbamazepine
4. Which of the following has cytoplasmic receptor:
   1. Epinephrine
   2. Insulin
   3. FSH

   --- Content provided by FirstRanker.com ---

   4. Cortisol
5. Therapeutic monitoring of plasma level of drug is done when using all of the following drugs except:
   1. Warfarin
   2. Gentamycin
   3. Phenytoin

   --- Content provided by‍ FirstRanker.com ---

   4. Cyclosporine
6. In which phase of clinical trials, post-marketing surveillance of a drug is carried out:
   1. Phase I
   2. Phase II
   3. Phase III

   --- Content provided by‍ FirstRanker.com ---

   4. Phase IV
7. Synaptic transmitter in the autonomic ganglion is:
   1. Adrenaline
   2. Dopamine
   3. Acetylcholine

   --- Content provided by​ FirstRanker.com ---

   4. Noradrenaline
8. All are cholinergic agents EXCEPT:
   1. Galantamine
   2. Donepezil
   3. Tacrine

   --- Content provided by⁠ FirstRanker.com ---

   4. Memantine
9. Methylphenidate is drug of choice for:
   1. Obsessive compulsive disorder
   2. ADHD (attention deficit hyperkinetic disorder)
   3. Enuresis

   --- Content provided by‍ FirstRanker.com ---

   4. Autism
10. All of the following are therapeutic uses of prazosin, except:
    1. Peripheral vascular disease
    2. Phaeochromocytoma
    3. Lupus Erythematosus

    --- Content provided by‌ FirstRanker.com ---

    4. Scorpion sting
11. Ethosuximide can be used for the treatment of:
    1. Generalized tonic clonic seizures
    2. Absence seizures
    3. Complex seizures

    --- Content provided by‌ FirstRanker.com ---

    4. Myoclonic seizures
12. Neural tube defect is an adverse effect of:
    1. Valproate
    2. Phenytoin
    3. Diazoxide

    --- Content provided by‌ FirstRanker.com ---

    4. None
13. Anti-Parkinsonism drug that is a selective COMT inhibitor:
    1. Entacapone
    2. Ropinirole
    3. Pergolide

    --- Content provided by FirstRanker.com ---

    4. Pramipexole
14. Drug useful in malignant hyperthermia is:
    1. Halothane
    2. Succinyl choline
    3. Dantrolene

    --- Content provided by‍ FirstRanker.com ---

    4. Haloperidol
15. Which of the following drug is not an opioid agonist?
    1. Heroin
    2. Ketamine
    3. Methadone

    --- Content provided by⁠ FirstRanker.com ---

    4. Codeine
16. Which of the following increases uric acid excretion?
    1. Allopurinol
    2. Aspirin
    3. Colchicine

    --- Content provided by‍ FirstRanker.com ---

    4. Probenecid
17. Most common cause of Mobius syndrome is use of which of the following drug in pregnancy?
    1. Misoprostol
    2. Thalidomide
    3. Methotrexate

    --- Content provided by‌ FirstRanker.com ---

    4. Dinoprostone
18. Gastric lavage is contraindicated in :
    1. Salicylate poisoning
    2. Kerosene poisoning
    3. Morphine poisoning

    --- Content provided by FirstRanker.com ---

    4. Organophosphate poisoning
19. For preanesthetic medication all of the drugs can be used except:
    1. Diazepam
    2. Glycopyrrolate
    3. Metoclopramide

    --- Content provided by‍ FirstRanker.com ---

    4. Phenobarbitone
20. Antihistaminic used for motion sickness is:
    1. Cetirizine
    2. Meclizine
    3. Promethazine

    --- Content provided by‍ FirstRanker.com ---

    4. Fexofenadine

Q.2 Answer in short [any five]: [3*5=15]

1. Write a note on rational use of medicines.
2. What is microsomal enzyme induction? Describe possible consequences of microsomal enzyme induction with examples.

--- Content provided by‌ FirstRanker.com ---

3. Explain potency and efficacy with the help of a suitable diagram.
4. Mention the uses of anticholinergic drugs.
5. Discuss the side effects and contraindications to propranolol.
6. Give pharmacological basis for use of adrenaline in anaphylactic shock.

Q.3 Write answers in details [any three]: [5*3=15]

--- Content provided by FirstRanker.com ---

1. Describe mechanism of action and adverse effects of any 3 drugs from different groups used in treatment of glaucoma.
2. Describe the process of synthesis, storage, release and uptake of catecholamine.
3. Classify anti-cholinesterases. Describe the pharmacotherapy of organophosphorus poisoning.
4. Define Adverse drug reaction and pharmacovigilance. Describe teratogenicity in detail.

Q.4 Case based questions: [10*1=10]

--- Content provided by‍ FirstRanker.com ---

A 35-year-old man complains of breathlessness for 1 month which is increasing in frequency with 3-4 attacks per week. Breathlessness is seen while doing his day-to-day activities. Patient is provisionally diagnosed as moderate persistent bronchial asthma. He is prescribed Metered dose inhaler of formoterol and budesonide.

1. What is the advantage of combining formoterol and budesonide in this patient? 2
2. Mention the advantages of giving the above drugs in metered dose inhaler as compared to oral route. 2
3. Which side effects can occur in this patient due to the prescribed drugs? 2
4. If this patient brought to emergency department as 'status asthamaticus' what treatment should be given? 4

--- Content provided by‍ FirstRanker.com ---

Section II

Q.5 Answer in short [any five]: [3*5=15]

1. Write a note on bioavailability of a drug.
2. Classify drugs used in cough. Describe dextromethorphan in short.
3. Describe the treatment of methyl alcohol poisoning.

--- Content provided by​ FirstRanker.com ---

4. Enumerate second generation antihistaminics. Mention their uses.
5. Write a note on prophylaxis of migraine.
6. Enlist selective serotonin reuptake inhibitors and their therapeutic uses.

Q.6 Write answers in details [any three]: [5*3=15]

1. Classify Nonsteroidal anti-inflammatory drugs (NSAIDs). Describe uses and adverse effects of aspirin.

--- Content provided by‍ FirstRanker.com ---

2. Compare and contrast benzodiazepines and barbiturates.
3. Enumerate commonly used drugs for generalized tonic clonic seizure. Describe briefly the mechanism of action and adverse effects of any two of them.
4. Classify antirheumatoid drugs. Describe mechanism of action and adverse effects of any three DMARDS (Disease modifying antirheumatic drugs).

Q.7 Case based questions: 10*1=10

A 30 years old man had a gradual onset of delusions and auditory hallucinations. He was diagnosed as schizophrenia by a psychiatrist and started him on tab. Haloperidol 2mg twice daily. A few weeks later although he improved clinically, he developed stiffness and rigidity of upper and lower limbs. He was diagnosed as drug induce parkinsonism.

--- Content provided by‍ FirstRanker.com ---

1. Explain the basis of drug induced parkinsonism. Which drug should be Started in this patient for treatment of drug induced parkinsonism? Why? 1+1+2
2. Describe the adverse effects of the drug used for this patient. 4
3. Enumerate antipsychotic drugs which have less chances of drug induced Parkinsonism and can be used in this patient. 2

*****

--- Content provided by‌ FirstRanker.com ---