Download VNSGU MBBS RAN 2106000102020102 Pharmacology Paper II March2023 Question Paper

RAN-2106000102020102

II M.B.B.S. Examination March - 2023

Pharmacology

--- Content provided by⁠ FirstRanker.com ---

? : / Instructions

(?) ? ? ? ? ? ? ? ?.

Fill up strictly the details of signs on your answer book

Name of the Examination:

II M.B.B.S.

--- Content provided by​ FirstRanker.com ---

Name of the Subject:

Pharmacology

Subject Code No.: 2106000102020102

(2) Encircle the single most appropriate answer.

(3) Each question carries one mark and there is no negative marking.

--- Content provided by⁠ FirstRanker.com ---

(4) Overwriting is not allowed.

Q.1 Multiple Choice Questions. (MCQs) [Marks 20]

1. Which diuretic is preferred in cirrhotic ascites ?
   1. Furosemide
   2. Spironolactone
   3. Acetazolamide

   --- Content provided by⁠ FirstRanker.com ---

   4. All of the above
2. A clinician diagnosed isoniazid induced neurological disturbances in a 30-year-old male patient on anti-tubercular drug regimen. Which vitamin should be prescribed?
   1. Vitamin B1
   2. Vitamin B6
   3. Vitamin B12

   --- Content provided by​ FirstRanker.com ---

   4. Vitamin B2
3. The management of thyrotoxicosis crisis includes all the following except:
   1. Propranolol
   2. Hydrocortisone
   3. Oral I¹³¹

   --- Content provided by⁠ FirstRanker.com ---

   4. Propylthiouracil
4. Combine oral contraceptive pill reduces the risk of:
   1. Breast cancer
   2. Ovarian cancer
   3. Cervical cancer

   --- Content provided by‌ FirstRanker.com ---

   4. Vaginal cancer
5. Which drug should not be given in pregnancy?
   1. Labetalol
   2. Hydralazine
   3. ACE inhibitors

   --- Content provided by FirstRanker.com ---

   4. Methyldopa
6. Which of the following statements about octreotide is FALSE ?
   1. It is used for the treatment of acromegaly
   2. It stops oesophageal variceal bleeding
   3. It can be used for the management of secretory diarrhoea

   --- Content provided by‌ FirstRanker.com ---

   4. It is effective orally
7. The following antianginal drug is most likely to produce tachycardia as a side effect:
   1. Amlodipine
   2. Nifedipine
   3. Diltiazem

   --- Content provided by‍ FirstRanker.com ---

   4. Verapamil
8. When are proton pump inhibitors most effective ?
   1. After meals
   2. Along with H2 blockers
   3. Shortly before meals

   --- Content provided by​ FirstRanker.com ---

   4. During prolonged fasting periods
9. Which of the following purgative increases the fecal bulk due to their water absorbing and retaining capacity?
   1. Methyl cellulose
   2. Lactulose
   3. Liquid paraffin

   --- Content provided by‌ FirstRanker.com ---

   4. Dioctyl sodium sulfosuccinate
10. The drug of choice for neurocysticercosis is :
    1. Albendazole
    2. Niclosamide
    3. Praziquantel

    --- Content provided by‌ FirstRanker.com ---

    4. Ivermectin
11. The multidrug therapy of leprosy is superior to monotherapy on the following basis:
    1. It prevents emergence of dapsone resistance
    2. It is effective in cases with primary dapsone resistance
    3. It shortens the total duration of drug therapy and improves compliance

    --- Content provided by‌ FirstRanker.com ---

    4. All of the above
12. Dobutamine is preferred over dopamine in cardiogenic shock because of its relatedness to :
    1. Better cardiac stimulation
    2. Less peripheral vasoconstriction
    3. Lower risk of cardiac arrhythmias

    --- Content provided by FirstRanker.com ---

    4. More CNS stimulation
13. Which antifungal agent is effective in both dermatophytosis as well as systemic mycosis :
    1. Amphotericin B
    2. Griseofulvin
    3. Clotrimazole

    --- Content provided by⁠ FirstRanker.com ---

    4. Ketoconazole
14. On which enzymes do statins act?
    1. Acyl CoA synthetase
    2. Acyl CoA reductase
    3. HMG CoA synthetase

    --- Content provided by FirstRanker.com ---

    4. HMG CoA reductase
15. 'Red man syndrome' has been associated with rapid intravenous injection of the following antibiotic :
    1. Vancomycin
    2. Clindamycin
    3. Cefoperazone

    --- Content provided by​ FirstRanker.com ---

    4. Piperacillin
16. Astringents are substances that:
    1. Irritate sensory nerve endings
    2. Precipitate proteins
    3. Penetrate target cell nucleus for their action

    --- Content provided by‍ FirstRanker.com ---

    4. All of the above
17. The following anticancer drug has high emetogenic potential:
    1. Vincristine
    2. Chlorambucil
    3. 6-Mercaptopurine

    --- Content provided by‌ FirstRanker.com ---

    4. Cisplatin
18. Which vitamin acts as a hormone ?
    1. Vitamin A
    2. Vitamin D
    3. Vitamin C

    --- Content provided by‌ FirstRanker.com ---

    4. Vitamin E
19. Select the drug combination which does NOT exhibit supra-additive synergism :
    1. Nalidixic acid + nitrofurantoin
    2. Amoxicillin + clavulanic acid
    3. Pyrimethamine + sulfadoxine

    --- Content provided by‌ FirstRanker.com ---

    4. Sulfamethoxazole + trimethoprim
20. Which of the following is NOT a valid indication for parenteral iron therapy?
    1. Inadequate response to oral iron due to patient non-compliance
    2. Anemia during pregnancy
    3. Severe anemia associated with chronic bleeding

    --- Content provided by FirstRanker.com ---

    4. Anemia in a patient of active rheumatoid arthritis

RAN-2106000102020102

PHARMACOLOGY PAPER II [Total Marks: 100

Time: 3 Hours ]

--- Content provided by‍ FirstRanker.com ---

Instructions:

(1) Answers should be precise and to the point.

(2) Give examples and figures if needed.

(3) First 20 mins have been allotted to solve multiple choice questions.

SECTION I

--- Content provided by⁠ FirstRanker.com ---

Q.1 Multiple choice questions. [1×20=20]

Q.2 Answer in brief. [any five] [3×5=15]

1. Describe various types of oral contraceptives. What is the rationale of combining estrogen and progesterone for contraception?
2. Write a note on management of erectile dysfunction.
3. Classify thyroid inhibitors. Write a note on thyroid storm management.

--- Content provided by⁠ FirstRanker.com ---

4. Outline the pharmacotherapy of psoriasis.
5. Write a note on drug therapy for constipation
6. Discuss briefly about heparin versus warfarin.

Q.3 Write short notes. [any three] [5×3=15]

1. Discuss various insulin preparations available. Write in detail about newer insulin preparations, their uses, pros and cons of each.

--- Content provided by‍ FirstRanker.com ---

2. Mention various thrombolytic agents. Describe their uses, mechanism of action and precautions required while using them.
3. Classify diuretic agents. Explain mechanism of action, uses and adverse effect profile of thiazide-like diuretics in detail.
4. Enumerate commonly used glucocorticoids. Discuss their adverse effect profile.

RAN-2106000102020102

Q.4 Case based questions : [10×1=10]

--- Content provided by FirstRanker.com ---

An adult 46-year-male, an executive in a multi-national company, has complaints of pain in abdomen since a month, along with occasional heart burn due to which he is unable to sleep. It worsens with ingestion of spicy and oily meals. After a thorough examination, physician diagnosed him as a case of peptic ulcer. Along with appropriate diet and lifestyle modifications, physician prescribed him anti-ulcer drugs.

Answer the following questions :

1. Enumerate various drugs from different groups which can be prescribed to him along with mechanism of action of any two drug classes. [4]
2. Write briefly about treatment regimens for H. pylori infection. [4]
3. Which drugs should be prescribed to the above patient if he develops gastroesophageal reflux disease (GERD)? [2]

--- Content provided by‌ FirstRanker.com ---

SECTION II

Q.5 Answer in brief. [any five] [3×5=15]

1. Write a short note on anti-hypertensives in pregnancy.
2. Elaborate mechanism of action, therapeutic uses and adverse effects of metronidazole.
3. Outline the pharmacotherapy of urinary tract infection.

--- Content provided by‌ FirstRanker.com ---

4. Describe measures to prevent antimicrobial drug resistance in detail.
5. Enumerate HMG-CoA reductase inhibitors along with their uses.
6. What is post exposure prophylaxis for HIV infection? Write two NACO recommended regimens for same.

Q.6 Write short notes. [any three] [5×3=15]

1. Classify fluoroquinolones. Describe the mechanism of action, therapeutic uses and adverse effects of any one fluoroquinolone.

--- Content provided by⁠ FirstRanker.com ---

2. Enlist anti-malarial drugs. Discuss the treatment regimens for chloroquine resistant P. falciparum malaria.
3. Describe in detail general principles for cancer chemotherapy.
4. Which are the drugs for congestive heart failure? Discuss the mechanism of action of digoxin in this scenario.

RAN-2106000102020102

Q.7 Case based questions : [10×1=10]

--- Content provided by‍ FirstRanker.com ---

A 50-year-old male patient was admitted to casualty with chief complaints of heaviness in chest, squeezing midsternal pain which was radiating to jaw and left shoulder without any precipitating factor, lasting for about few minutes. He was sweating profusely. His electrocardiogram showed ST segment elevation. He was diagnosed as having acute myocardial infarction.

Answer the following questions :

1. Write in detail about the management of above-mentioned diagnosis. [5]
2. Enumerate various anti-anginal drugs. [3]
3. What is the rationale of using ß blocker + long-acting nitrate combination in classical angina? [2]

--- Content provided by FirstRanker.com ---

Visit FirstRanker.com for more information.