Download VNSGU MBBS RAN 2106000102030101 Microbiology Paper I January2023 Question Paper

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RAN-2106000102030101

2^nd Year M.B.B.S. Examination January - 2023

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Microbiology : Paper - I

? : / Instructions

1. ? ? ? ? ? ? ? ?. Fill up strictly the details of signs on your answer book

   Name of the Examination:	2nd Year M.B.B.S.
   Name of the Subject:	Microbiology : Paper - 1
   Subject Code No.:	2106000102030101	Student's Signature

2. Draw a label diagram wherever required with blue pen/pencil only.
3. Short notes 100-150 words

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4. Write heading of each question properly.

SECTION - IA

(General Microbiology and Immunology)

1. Define Hypersensitivity reactions, Classification of Hypersensitivity reaction, write in detail about mechanism of type 1 hypersensitivity reactions, write methods for detection of Type 1 hyper sensitivity reactions.

   (12 marks)

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2. Write notes. (any four) (4 × 7 = 28 marks)

   1. Principle, applications and modifications of Polymerase Chain Reaction in patient care.
   2. Classification, types and diagnostic modalities of Immunodeficiency diseases.
   3. Define vaccine. Describe National Immunization Schedule and the types of vaccines used in it.

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   4. Moist heat sterilization: methods, principle, application and control.
   5. Mechanisms of transferable drug resistance in bacteria.

RAN-2106000102030101 ] [1] [P.T.O.]

3. Multiple Choice Questions. (10 Marks)

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   1. Which of the following is absent in Gram negative bacteria?
      1. Peptidoglycan
      2. LPS
      3. Teichoic acid
      4. Porin Channels

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   2. Resolution power of microscope can be improved by using?
      1. Oil
      2. Stain
      3. Lenses
      4. Condenser

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   3. Bacteria are uniformly stained in which of the following phase of growth curve?
      1. Lag phase
      2. Log phase
      3. Stationary phase
      4. Declining phase

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   4. All of the following are basic steps of PCR cycle EXCEPT:
      1. Denaturation
      2. Amplification
      3. Extension
      4. Gel documentation

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   5. The antibodies detectable in mothers milk are
      1. IgG
      2. IgA
      3. IgG & IgA
      4. IgG, IgA & IgM

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   6. If the infection occurs at a much higher rate than usual in a particular geographic area, it is known as:
      1. Epidemic
      2. Endemic
      3. Hyper endemic
      4. Sporadic

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   7. Active acquired immunity has following features EXCEPT
      1. It involves active functioning of host's immune system
      2. It is long lasting
      3. There is no latent period
      4. It is associated with immunological memory

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   8. A child with a history of repetitive intestinal worm infestation is likely to show an increase in the level of:
      1. IgG
      2. IgM
      3. IgE
      4. IgD

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   9. Type of hypersensitivity reaction in myasthenia gravis is:
      1. Type I
      2. Type II
      3. Type III
      4. Type IV

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RAN-2106000102030101 ] [2] [ Contd.]

10. Application of skin graft for the second time from the same donor will result in:
    1. First set rejection
    2. Second set rejection
    3. Both

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    4. None

SECTION - IB

(Infection of Blood stream, Cardiovascular system, Gastrointestinal tract, Hepatobiliary system)

1. A young adult female was admitted to the hospital with intense headache, abdominal discomfort for past 5 days. She had also developed fever which is of remittent type with gradual rise in a step ladder fashion. On examination, she was toxic with temperature of 101°F, tongue was coated and mild splenomegaly was present.

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   1. What is the most probable etiological diagnosis? (12 marks)
   2. Describe the pathogenesis of this condition.
   3. Explain the choice of test, sample collection and laboratory diagnosis. of the condition.
   4. Suggest preventive measures for the disease.

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2. Write notes. (any four) (4 × 7 = 28 marks)

   1. Hepatitis B virus: pathogenesis, laboratory diagnosis and prevention
   2. Mycotic food poisoning.
   3. Pyrexia of unknown origin: definition, causes and diagnostic test used
   4. Two common hemo parasitic infections with pathogenesis and laboratory diagnosis of any one of them.

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   5. Importance of effective communication skill in Doctor Patient relationship.

3. Multiple Choice Questions (10 Marks)

   1. Most common agent causing native valve endocarditis is:
      1. S.aureus
      2. S.epidermidis

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      3. Viridans streptococci
      4. Enterococci
   2. Which of the following infections causes Megaloblastic anemia:
      1. Babesia microti
      2. Diphyllobothrium latum

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      3. Bartonella bacilliformis
      4. Leishmania donovani

RAN-2106000102030101 ] [3] [P.T.O.]

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3. Antibodies against which of the following antigen appear in typhoid carrier:
   1. Vi antigen
   2. O antigen
   3. H antigen
   4. Capsular antigen

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4. Which of the following is the infective form of the malaria parasite to man:
   1. Merozoite
   2. Sporozoite
   3. Trophozoite
   4. Gametocyte

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5. Which of the following is responsible for transmission of HBV infection:
   1. HBsAg
   2. HBeAg
   3. HBcAg
   4. HBV DNA

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6. Single most important agent of traveler's diarrhea is:
   1. Enterotoxigenic E. coli
   2. Enteroaggregative E. Coli
   3. Campylobacter jejuni
   4. Non Typhodal salmonella

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7. Most common viral cause of gastroenteritis is:
   1. Rotavirus
   2. Norwalk virus
   3. Adenovirus
   4. Hepadnavirus

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8. A 35 year old male patient presented with complains for chronic indigestion and having diarrhoea alternating with constipation. He is a traveller and frequently consumes beef. The most appropriate investigation of choice to be advised in this case would be:
   1. Stool for toxin detection
   2. Stool for occult blood
   3. Stool for routine and microscopic examination
   4. Stool concentration technique

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9. Which of the following route has highest risk of transmission of HIV:
   1. Sexual
   2. Blood product
   3. Needle/syringe
   4. Mother to fetus

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10. Definitive host for Echinococcosis is:
    1. Man
    2. Dog
    3. Sheep
    4. Pig

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