Download VNSGU MBBS ND 2006000101030001 Biochemistry Paper I December2021 Question Paper

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ND-2006000101030001-O Seat No.

First Year M. B. B. S. Examination

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December - 2021

Biochemistry : Paper - 1

(New CBME Pattern)

Instruction :

? ? ? ? ? ? ? ?.

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Fillup strictly the details of signs on your answer book.

Name of the Examination:

First Year M. B. B. S.

Name of the Subject:

Biochemistry: Paper - 1

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Section A: MCQ (20 marks)

Instructions:

1. All questions are compulsory
2. Each MCQ has only one correct answer
3. One mark for correct answer. No negative marking

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1. Which of the following correctly describes the composition of the CSF
   1. It has the same osmolarity as blood
   2. It has the same pH as blood
   3. It is more alkaline than blood
   4. It contains higher glucose concentration than blood

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2. All of the following are functions of kidney, Except.
   1. Detoxification of Alcohol
   2. Formation of 1, 25 DHCC
   3. Excretion of hydrogen ions
   4. Stimulation of Erythropoiesis

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3. Parathyroid Hormone (PTH) is involved in:
   1. Activation of Vitamin D
   2. Increases the intestinal absorption of calcium
   3. Decreases the intestinal absorption of calcium
   4. Increases the synthesis of thyroid hormones

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4. People with diabetes mellitus are prone to develop cataracts because their elevated blood glucose concentration:
   1. Inhibit gluconeogenesis
   2. Increase glycosylate hemoglobin
   3. Increase glycogen synthesis within the lens
   4. Allow aldose reductase to reduce glucose to sorbitol

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5. Facilitated diffusion transport molecules:
   1. Against concentration gradient
   2. With the concentration gradient
   3. Always use energy
   4. Does not require carrier protein

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6. Lactic acidosis is seen in the following cases, EXCEPT:
   1. Oxidative phosphorylation disorders (Mitochondrial)
   2. Defective metabolism of pyruvate
   3. Excessive ingestion of alcohol
   4. Deficiency of glucose-6-phosphate dehyrogenase

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7. In human, vitamin C is not synthesized, because:
   1. Absence of Xylitol reductase
   2. Absence of L-gulonolactone oxidase
   3. Absence of Glucose 6-phosphate dehydrogenase
   4. Absence of Xylulose dehydrogenase

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8. Fatty acid synthesis differs from beta oxidation in all, EXCEPT:
   1. Uses NADPH as reducing power
   2. Requires coenzyme A
   3. Catalyzed by multienzyme complex
   4. Activated by insulin

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9. The plasma sample of 35 years old man after overnight refrigeration showed a creamy layer on top and opalescence below. The condition which is excluded is:
   1. Diabetes mellitus
   2. Alcoholism
   3. Hypothyroidism
   4. Familial hypercholesterolemia

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10. All of the following fatty acid synthesized by humans EXCEPT
    1. Palmitoleate
    2. Oleate
    3. Arachidonate
    4. Linoleate

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11. Which of the following is rate limiting enzyme in HMP shunt?
    1. Transketolase
    2. Phosphogluconate dehydrogenase
    3. Ribulose 5 phosphate
    4. Glucose 6 phosphate dehydrogenase

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12. Which of the following stops respiratory chain?
    1. Unavailability of O2
    2. Unavailability of ADP
    3. Unavailability of NADH
    4. All of the above

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13. Elevated levels of one of the following lipid parameter is associated with pancreatitis:
    1. Total cholesterol
    2. LDL-cholesterol
    3. HDL-cholesterol
    4. Triacylglycerol

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14. All the following statements regarding hexokinase and glucokinase are true, EXCEPT
    1. Hexokinase is Less specific than glucokinase
    2. Glucokinase is induced by glucagon
    3. Glucokinase is more in the liver
    4. They differ in their Km for the substrate

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15. Liver can not utilized ketone bodies due to the lack of enzyme
    1. Thiolase
    2. Thiophorase
    3. HMG CoA lyase
    4. Beta hydroxy butyrate dehydrogenase

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16. Wilson disease occurs due to defect in which transport protein?
    1. ATP-7A
    2. ATP-7B
    3. ABC-A1
    4. ABC-C2

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17. Earliest indicator of iron deficiency anemia is
    1. S. Ferrtin
    2. S. TIBC
    3. S. Iron
    4. S. Transferrin

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18. Which glucose transporter is under control of insulin?
    1. GLUT2
    2. GLUT3
    3. GLUT4
    4. GLUT5

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19. LDL receptor defect results in the following type of hyperlipidemia
    1. Type I
    2. Type IIA
    3. Type IIB
    4. Type IV

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20. Cancer cell derive nutrition from:
    1. Glycolysis
    2. Oxidative phosphorylation
    3. Glycogenolysis
    4. From a fast food

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