| Date of issue : | Centre : | 
| Sup. Sign. : | Seat No.: | 
ND-2006000101030002-O Seat No.
First Year M. B. B. S. Examination
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December - 2021
Biochemistry : Paper - II
(New CBME Pattern)
Time: Hours] [Total Marks : 80
Instruction :
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? ? ? ? ? ? ? ?.
Fillup strictly the details of signs on your answer book.
| Name of the Examination: First Year M. B. B. S. | Seat No.: | |
| Name of the Subject: Biochemistry: Paper - II | ||
| Subject Code No.: | Section No. (1,2): Nil | Student's Signature | 
Section A: MCQ (20 marks)
Instructions:
- All questions are compulsory
- Each MCQ has only one correct answer
- One mark for correct answer. No negative marking
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- Michaelis constant (Km) of an enzyme is - Dependent upon the enzyme concentration
- Numerically equal to ½ Vmax
- Independent of pH
- Numerically equal to substrate concentration at ½ Vmax
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- Creatine kinase level in serum is increased in: - Myocardial infarction
- Infective hepatitis
- Prostate cancer
- Intravascular hemolysis
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- Which enzyme is used for preparing recombinant DNA molecules? - Restriction endonuclease
- DNA Polymerase
- RNA Polymerase
- Topoisomerase
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- Southern blotting analysis is used for all, except: - Detecting the presence of a mutant gene
- Studying a microarray
- Visualizing DNA profile
- Detecting Restriction fragment length polymorphism
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- Deficiency of thyroxine results in: - Graves disease
- Cushings syndrome
- Myxedema
- Thyrotoxicosis
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- Heme biosynthesis does not occur in - Osteocytes
- Liver
- RBC
- Erythroid cells of marrow
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- Which vitamin is required for carboxylation of clotting factors - Vitamin A
- Vitamin D
- Vitamin E
- Vitamin K
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- Mitochondrial DNA is - Closed circular
- Nicked circular
- Linear
- Open circular
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- Northern blot is for - DNA
- RNA
- Protein
- DNA protein interaction
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- All are regulatory sequences on DNA, EXCEPT: - Attenuator sequences
- Enhancer sequences
- Consensus sequences
- Promoter sequences
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- Tumor suppressor genes are sometimes called: - Antioncogenes
- Proto Oncogenes
- Oncogenes
- Proximate Carcinogens
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- Conversion of allopurinol to alloxanthine is an example of: - Competitive inhibition
- Uncompetitive inhibition
- Non-competitive inhibition
- Suicide Inhibition
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- Radioisotopes used for treatment of thyroid cancer is - 131I
- 198Au
- 139Cs
- 182Ta
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- Chaperon proteins play a role in - Protein folding
- Protein misfolding
- Denaturation
- All the above
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- During denaturation, all the levels of a protein structure are disrupted, Except: - Primary Structure
- Secondary Structure
- Tertiary Structure
- Quaternary Structure
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- Catabolite gene activator protein along with cyclic AMP (CAP - CAMP) is associated with the function of - Lac operon
- Tryptophan operon
- Both of the above
- None of the above
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- Corona virus is positive stranded RNA virus having lipid bilayer with M spike protein in it. Which of the following nitrogen base is absent in genome of this virus? - Guanine
- Cytosine
- Thymine
- Adenine
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- The receptor of the following hormone has intrinsic tyrosine kinase activity - Insulin
- ADH
- Steroids
- Glucagon
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- Positive nitrogen balance is seen in - Starvation
- Wasting diseases
- Growing age
- Intestinal malabsorption
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- Transmethylation of guanidoacetate gives - Creatine
- Creatinine
- Choline
- n-methyl nicotinamide
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