Download VNSGU MBBS ND 2006000101030002 Biochemistry Paper II December2021 Question Paper

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ND-2006000101030002-O Seat No.

First Year M. B. B. S. Examination

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December - 2021

Biochemistry : Paper - II

(New CBME Pattern)

Time: Hours] [Total Marks : 80

Instruction :

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Fillup strictly the details of signs on your answer book.

Section A: MCQ (20 marks)

Instructions:

1. All questions are compulsory

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2. Each MCQ has only one correct answer
3. One mark for correct answer. No negative marking

1. Michaelis constant (Km) of an enzyme is
   1. Dependent upon the enzyme concentration
   2. Numerically equal to ½ Vmax
   3. Independent of pH

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   4. Numerically equal to substrate concentration at ½ Vmax
2. Creatine kinase level in serum is increased in:
   1. Myocardial infarction
   2. Infective hepatitis
   3. Prostate cancer

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   4. Intravascular hemolysis
3. Which enzyme is used for preparing recombinant DNA molecules?
   1. Restriction endonuclease
   2. DNA Polymerase
   3. RNA Polymerase

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   4. Topoisomerase
4. Southern blotting analysis is used for all, except:
   1. Detecting the presence of a mutant gene
   2. Studying a microarray
   3. Visualizing DNA profile

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   4. Detecting Restriction fragment length polymorphism
5. Deficiency of thyroxine results in:
   1. Graves disease
   2. Cushings syndrome
   3. Myxedema

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   4. Thyrotoxicosis
6. Heme biosynthesis does not occur in
   1. Osteocytes
   2. Liver
   3. RBC

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   4. Erythroid cells of marrow
7. Which vitamin is required for carboxylation of clotting factors
   1. Vitamin A
   2. Vitamin D
   3. Vitamin E

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   4. Vitamin K
8. Mitochondrial DNA is
   1. Closed circular
   2. Nicked circular
   3. Linear

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   4. Open circular
9. Northern blot is for
   1. DNA
   2. RNA
   3. Protein

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   4. DNA protein interaction
10. All are regulatory sequences on DNA, EXCEPT:
    1. Attenuator sequences
    2. Enhancer sequences
    3. Consensus sequences

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    4. Promoter sequences
11. Tumor suppressor genes are sometimes called:
    1. Antioncogenes
    2. Proto Oncogenes
    3. Oncogenes

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    4. Proximate Carcinogens
12. Conversion of allopurinol to alloxanthine is an example of:
    1. Competitive inhibition
    2. Uncompetitive inhibition
    3. Non-competitive inhibition

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    4. Suicide Inhibition
13. Radioisotopes used for treatment of thyroid cancer is
    1. ¹³¹I
    2. ¹⁹⁸Au
    3. ¹³⁹Cs

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    4. ¹⁸²Ta
14. Chaperon proteins play a role in
    1. Protein folding
    2. Protein misfolding
    3. Denaturation

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    4. All the above
15. During denaturation, all the levels of a protein structure are disrupted, Except:
    1. Primary Structure
    2. Secondary Structure
    3. Tertiary Structure

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    4. Quaternary Structure
16. Catabolite gene activator protein along with cyclic AMP (CAP - CAMP) is associated with the function of
    1. Lac operon
    2. Tryptophan operon
    3. Both of the above

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    4. None of the above
17. Corona virus is positive stranded RNA virus having lipid bilayer with M spike protein in it. Which of the following nitrogen base is absent in genome of this virus?
    1. Guanine
    2. Cytosine
    3. Thymine

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    4. Adenine
18. The receptor of the following hormone has intrinsic tyrosine kinase activity
    1. Insulin
    2. ADH
    3. Steroids

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    4. Glucagon
19. Positive nitrogen balance is seen in
    1. Starvation
    2. Wasting diseases
    3. Growing age

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    4. Intestinal malabsorption
20. Transmethylation of guanidoacetate gives
    1. Creatine
    2. Creatinine
    3. Choline

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    4. n-methyl nicotinamide

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