M-4005
First Year M. B. B. S. Examination
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July 2015
Biochemistry : Paper - I
Time : 1 Hour & 50 Minutes] [Total Marks : 40
Instructions :
(1) Fill up strictly the details of signs on your answer book.
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Name of the Examination:
FIRST YEAR M. B. B. S.
Name of the Subject:
BIOCHEMISTRY - 1
(2) Write each section in separate answer book.
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(3) Draw figures wherever possible.
SECTION - I
1 Short note : (2 out of 3) 8
(a) Describe the stage of absorption, transport and storage of iron in the body. Add a note on disorder associated with defective iron metabolism.
(b) Degradation and clinical significance of cholesterol.
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(c) Role of kidney in maintenance of acid-base balance.
2 Describe in brief : (4 out of 6) 12
(a) Metabolic acidosis.
(b) Mucopolysaccharides and their biomedical importance.
(c) Function of prostaglandin.
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(d) Chemiosmotic coupling theory for Oxidative phosphorylation.
(e) Plasma lipid profile.
(f) ß oxidation of fatty acid and its energetics.
SECTION - II
Case with 5 questions:
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A 56 yr old man with known history of diabetes mellitus (DM) is brought to the hospital in a semiconscious state. He has rapid breathing his relative says that due to a family functions, his diet and sleep have been erratic. The physician advises to routine blood test - RBS, Blood Urea, Creatinine, HBA1C and Electrolytes.
(1) Write the Normal Range of random, fasting and post-prandial plasma glucose.
(2) What is the utility of HBA1C estimation?
(3) What is the WHO criteria for diagnosis of diabetes mellitus?
(4) Enumerate the three cardinal symptoms of diabetes mellitus.
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(5) Enumerate any two late complication of diabetes.
Answer in few line: (5 out of 7)
(1) TCA cycle is Amphibolic in nature.
(2) Selenium is an Antioxidant Mineral.
(3) LDL cholesterol is called as bad cholesterol.
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(4) Venom of viper snake bite leads to haemolysis.
(5) Fatty liver is commonly observed in chronic alcoholics.
(6) Sucrose is non reducing sugar.
(7) Ketoacidosis is potentially dangerous to the body.
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