Download VNSGU MBBS First Year 2016 Dec ER 4005 Biochemistry Paper I Question Paper

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ER-4005

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First Year M. B. B. S. Examination

December 2016

Biochemistry : Paper - I

Time: 2 ¹/₂ Hours] [Total Marks: 50

Instruction :

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Fill up strictly the details of signs on your answer book.

Name of the Examination:

First Year M. B. B. S.

Name of the Subject:

Biochemistry: Paper - 1

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Subject Code No.: 4 0 0 5 Section No. (1,2,...) 182

Seat No.:

Student's Signature

SECTION - I

1. Short Notes: (2 out of 3) 8

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   1. Describe the sources, biochemical functions and disorders of calcium metabolism.

   2. What is gluconeogenesis? Describe the gluconeogenesis from various substrates.

   3. Buffer system of blood for maintenance of pH.

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2. Short Notes: (4 out of 6) 12

   1. Lipoproteins: types, composition and functions.

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   2. Digestion, absorption, transport, functions of Iron.

   3. Essential Fatty Acids and their significance.

   4. Lactose intolerance.

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   5. Cori's cycle.

   6. Liver function tests.

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ER-4005] 1 [Contd...

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3. Answer in one or two lines: (5 out of 6) 5

   1. Lead toxicity effects.

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   2. Functions of prostaglandins.

   3. Blood is collected in fluoride bulb for estimation of blood glucose level.

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   4. Function and deficiency manifestation of iodine.

   5. Significance of HMP shunt.

   6. Ketone bodies functions.

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SECTION - II

4. Read the following case and answers the questions: 10

   A 45 year old male patient having Type 2 Diabetes Mellitus presented with complaints of impaired vision and feeling of tiredness. Ophthalmic examination showed Cataract in both eyes. His Biochemical test reports were: Fasting Plasma Glucose = 300 mg/dl, Urine Glucose ++++, Glycated Hb (HbA1C) = 12%.

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   1. Why Cataract develops more commonly and earlier in patients of Diabetes Mellitus?

   2. What is Glycated Hb and significance of estimating it?

   3. What are other late complications of Diabetes Mellitus besides cataract?

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   4. Differentiate between Type 1 and Type 2 Diabetes Mellitus.

   5. How much is the renal threshold for Glucose? What are the other causes of Glycosuria?

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5. Write justification: (5 out of 7) 10

   1. Starvation causes ketoacidosis.

   2. In RBCs, end product of Glycolysis is always lactate.

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   3. LDL cholesterol is bad cholesterol.

   4. TCA cycle is amphibolic pathway.

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ER-4005] 2 [Contd...

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6. 1. Hemolysed serum sample is not suitable for estimation of potassium.

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   2. Aspirin is used as anti-inflammatory drug.

   3. Deficiency of enzyme Glucose 6 Phosphate Dehydrogenase (G6PD) causes drug induced hemolysis.

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6 Answer in one or two lines: (5 out of 6) 5

1. Functions of selenium

2. Functions of magnesium

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3. Uncouplers

4. Functions of dietary fibres.

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5. Physiologically important glycosides

6. Specific dynamic action of food.

ER-4005] 3 [100]

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