Download VNSGU MBBS First Year 2017 December B 3705 Biochemistry Paper II Question Paper

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B-3705

First M. B. B. S. Examination

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December - 2017

Biochemistry: Paper - II

Time: 1 1/2 Hours

[Total Marks: 50]

Instruction:

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Fill up strictly the details of signs on your answer book.

Name of the Examination:

First M. B. B. S.

Name of the Subject:

Biochemistry: Paper - II

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Subject Code No.: 3705 Section No. (1, 2...) 182

SECTION - I

1. Short notes: (2 out of 3) 8
   1. Describe Primary & Secondary structures of protein.
   2. Vitamin D - Sources, functions and deficiency manifestations.
   3. DNA Replication.

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2. Describe in brief: (4 out of 5) 12
   1. Explain "Ammonia is toxic to brain".
   2. Molecular basis of Sickle cell anaemia.
   3. Polymerase chain reaction.
   4. Characteristic of Genetic Code.

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   5. Hyperuricemia and gout.
3. Answer in one or two lines: (5 out of 6) 5
   1. Type of Mutation.
   2. What are Xenobiotics?
   3. Mention important compounds synthesized from tyrosine.

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   4. Enzyme pattern in diagnosis of acute myocardial infarction.
   5. Zwitter ions.
   6. Competitive inhibition of enzymes.

B-3705 ] 1 [ Contd...

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SECTION – II

4. Clinical Case with 5 questions: 10

   56 year male patient came in emergency with alter-conciuosness & haemetemesis. He was suffering from chronic cirrhotic liver disease due to chronic alcoholism. On examination , it was found that he has edema on both lower limb, fluid collection in peritoneal cavity (Ascites), yellowish discoloration of skin & sclera (icterus). On blood investigation following was found.

   Blood Glucose: 50 mg%,

   APTT Test: 60 second (Increase)

   Serum Protein: 5.5 gm%

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   Serum Albumin : 2.0 gm%

   Serum Total Billirubin : 20 mg%

   Physician advised to give Following treatment

   10% Dextrose with Thiamine (Vit-B1), 10% Albumin, Vitamin K, Oral Neomycin (Antibiotic)

   Questions:

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   1. Explain biochemical reason for edema & ascites in this patient.
   2. Explain biochemical reason for yellowish discoloration of skin & sclera?
   3. What is reason for increase APTT in this case ?
   4. How Oral Neomycin (Anti-microbial, Antibiotic) reduces risk of cerebral encephalopathy?
   5. What is role of Vitamin K in this case?

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5. Answer in few lines (5 out of 7) 10
   1. Alpha-1 antitrypsin deficiency causes emphysema.
   2. Telomerase is essential for dividing cell.
   3. Haemoglobin is good blood buffer.
   4. In the presence of uncouplers of oxidative phosphorylation, body temperature rises.

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   5. Bile salts are detected in the urine of obstructive jaundice.
   6. Strict vegetarian may suffer from vitamin B12 deficiency.
   7. Write different isoenzymes of CPK and LDH.

B-3705 ] 2 [ Contd...

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6. Answer in one or two lines: (5 out of 6) 5
   1. Definition & example of Co-Enzyme
   2. Type of RNA
   3. Role of 2, 3 BPG in oxygen transport by hemoglobin.
   4. Why tyrosine becomes an essential amino acid for patients of phenylketoneuria?
   5. Role of ATP in body

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   6. Major biochemical functions of liver.

B-3705] 3 [100]

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