Download VNSGU MBBS First Year 2018 July R 3704 Biochemistry Paper I Question Paper

R-3704

First Year M. B. B. S. Examination

July - 2018

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Biochemistry: Paper - I

Time: 2 Hours] [Total Marks: 50

Instruction :

Fill up strictly the details of signs on your answer book.

Name of the Examination:

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FIRST YEAR M. B. B. S.

Name of the Subject:

BIOCHEMISTRY: PAPER-1

Subject Code No.: 3 7 0 4 Section No. (1,2...) 1&2

Seat No.:

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Student's Signature

SECTION-I

1. Short notes: (2 out of 3) 2×4=8

   1. Describe electron transport chain and its inhibitors.
   2. Degradation and clinical significance of cholesterol.

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   3. Describe how carbohydrates are digested and absorb in the body.

2. Short notes: (4 out of 6) 4×3=12

   1. Principle and application of electrophoresis
   2. Homeostasis of plasma calcium level

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   3. Gluconeogenesis and its significance
   4. Protein energy malnutrition
   5. Describe reverse cholesterol transport and HDL cycle
   6. Renal function test.

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3. Answer in one or two line: (5 out of 6) 5×1=5

   1. Biochemical role of selenium.
   2. Name any four Tumor marker.
   3. Renal glycosuria.
   4. Mention any two phospholipids and its specific function.

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   5. Principle of ELISA.
   6. Importance of benedict test.

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SECTION - II

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4. Read the following case and answer the questions: 5×2=10

   A 14 year old boy was brought to a hospital in a comatose state with fruity smell. The doctor on duty got his RBS and ketone bodies in urine analyzed. RBS was around 450 mg/dl and ketone bodies in urine was 4+. The urine sugar was also 4+. The patient was dehydrated and there was low serum potassium. His arterial blood gas analysis revealed:

   Blood pH: 7.2, HCO3: 14 mmol/L, pCO2: 30 mmHg

   1. What is normal range of Random, Fasting and Postprandial plasma Glucose ?
   2. Why Diabetes mellitus causes elevated serum ketone bodies?

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   3. How will you differentiate between the diabetic ketoacidosis and starvation ketoacidosis ?
   4. Describe the major functions of Insulin.
   5. What is the reason of fruity smell?

5. Write justification (5 out of 7) 5×2=10

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   1. Ethanol is used to treat methanol poisoning.
   2. Human being can not digest cellulose.
   3. Premature baby tends to develop Respiratory distress syndrome.
   4. Hyperkalemia is usually associated with acidosis while hypokalemia is seen during alkalosis.
   5. Iron deficiency anemia is observed in copper deficiency.

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   6. Aspirin is used as an anti-inflammatory agent.
   7. Excessive alcohol intake leads to fatty liver.

6. Answer in one or two line: (5 out of 6) 5×1=5

   1. Biochemical changes in alcoholism.

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   2. Normal level of BMR (Basal Metabolic rate).
   3. Application of isotopes for diagnosis.
   4. Name of lipoprotein.
   5. Name of glycogen storage diseases.
   6. Write three main functions of prostaglandin.

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