RAN-3705
Medical Faculty 1st MBBS Biochemistry Examination
March / April - 2019
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Biochemistry Theory - Paper 2
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Fill up strictly the details of signs on your answer book
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Name of the Examination:
Medical Faculty 1st MBBS Biochemistry
Name of the Subject:
Biochemistry Theory - Paper 2
Subject Code No.: 3 7 0 5
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SECTION - I
Q-1 Short notes (2 out of 3) 08 marks
- Tertiary structure of protein
- mRNA
- Thalassemia
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Q-2 Describe in brief (4 out of 6) 12 marks
- Xenobiotics metabolism
- Isoenzymes of diagnostic importance
- Transaminase and glutamate dehydrogenase
- DNA fingerprinting
- Noncompetitive enzyme inhibition
- Post translational modification of collagen
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SECTION - II
Q-3 Answer in one or two lines (5 out of 6) 05 marks
- tRNA
- Urea cycle
- Role of recombinant DNA technology in medicine
- Genetic code
- Proinsulin, Insulin, Pre-pro insulin (arrange in increasing order of size)
- Protein energy malnutrition
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Q-4 Clinical Case with 5 questions 10 marks
A 45 year old man presented with severe pain and weakness. He had repeated infection and fever off-an-on.
His bone marrow biopsy showed an excess of plasma cells. His serum total protein was 9.8 gm/dL and Albumin was 2.0 gm/dL. Serum electrophoresis showed sharp abnormal band between beta globulin and gamma globulin. On Immunofixation test, the sharp band was found to be made up of only IgA with only kappa light chain. Free kappa light chain were very high as compared to free lambda chain in serum. Multiple myeloma was diagnosed. Treatment with proteosome-inhibitor (Bortezomib) and Thalidomide-group of drugs was started.
- Interpret serum albumin, globulin and A/G ratio in the patient.
- Explain relationship of kappa and lambda light chain with structure of IgG.
- Which of the tests done in this patient indicate presence of "M-Band"? Why it is called "M Band"
- Write function of proteosome in cell?
- Write this patient's total protein and albumin results in gm/L units.
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Q-5 Answer in few lines (5 out of 7) 10 marks
- 5-flurouracil is an anticancer drug
- Bilirubin is not found in urine of patients with hemolytic jaundice
- Osteogenesis imperfecta
- Phenylbutyrate is used in treatment of hepatic enchephelopathy
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Q-6 Answer in one or two lines (5 out of 6) 05 marks
- At high altitude, RBC 2-3 BPG is increased.
- Dietary fibers are essential components of food.
- Histidine in hemoglobin is good buffer.
- Iron absorption
- Nucleotide excision repair
- Feedback regulation of enzymes
- Telomerase
- stem cell therapy
- DNA damage
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