Download MBBS (Bachelor of Medicine, Bachelor of Surgery) Pathology PPT 11 Non Neoplastic Diseases of Cns Lecture Notes
Non-neoplastic diseases of
the Central Nervous system
Its special
15% Cardiac output
20% O2 consumption
Physical y isolated
Vascular barrier
Circulation priority
Metabolic privilege
Incredibly complex
Even dies uniquely!
But it deserves al
the attention
because it performs
And very intricately organized
Well cushioned and fed
BUT
Radial & Tangential
migration
D
E
Many things can go wrong
ZIKA
V
Virus!!
E
L
O
P
M
E L
N Y
T
A
L
A
N
O
M
A
D
E
Many things can go wrong
V
E
L
O
P
M
E L
N Y
T
A
L
A
N
O
M
A
D
E
Many things can go wrong
V
E
L
O
P
M
E L
N Y
T
A
L
A
N
O
M
A
D
E
Many things can go wrong
V
E
L
O
P
M
E L
Heterotopia
N Y
T
A
L
A
N
O
M
A
D
E
Many things can go wrong
V
E
L
O
P
M
E L
N Y
T
A
L
A
N
O
M
A
Many things can go wrong
Communicating Vs Non-communicating
H
Primary Vs Secondary
Y
D
R
O
C
E
P
H
A
L
U
S
Many things can go wrong
C
E
? Vasogenic
R
? Cytotoxic
E
? Interstitial
B
R
A
L
E
D
E
M
A
Many things can go wrong
H
E
R
N
I
A
T
Life
I
threatening
O
N
Many things can go wrong
H
E
M
O
R
R
H
A
G
E
C
E
Many things can go wrong
Non-hemorrhagic
R
Hypoxia
E
Ischemia
Infarct
B
Hemorrhagic
R
O E
V A
A S
S E
C S
U
L
A
R
D
I
S
C
E
Many things can go wrong
R
E
B
Hippocampus
R
Cerebel um (Purkinje)
O
Cerebral cortex
E
Does it affect al areas equal y?
(Pyramidal)
V A
Cardiac arrest
A
Shock
S
S
Hypotension
E
C
Does it affect al cel s equal y?
S
U
Neurons>> Glial cel s
L
A
R
Very severe ischemia: Diffuse neuronal
damage
COMA
D
I
SC
E
Many things can go wrong
R
E
B
R
O
Embolism
E
V A
A S
Thrombus
S E
C S
U
Vasculitis
L
A
R
D
I
S
C
E
R
E
Liquefactive
B
necrosis
R
O E
V A
A S
S E
C S
U
L
A
R
D
I
SC
E
Deep
R
Brain
E
B
Lacunar infarcts
R
O E
Slit
V
haemorrhages
A
A S
S E
C S
Hypertensive
U
encephalopathy
L
A
R
Intraparenchymal
haemorrhage
D
I
S
C
E
R
E
B
R
O E
V A
A S
S E
C S
U
L
A
R
D
I
SC
INFARCT
E
Many things can go wrong
R
E
B
R
O E
V A
A S
S E
C S
U
L
A
R
D
I
S
C
E
RED NEURONS
R
E
B
R
O E
V A
A S
S E
C S
U
L
A
R
D
I
SC
E
R
E
B
R
O E
V A
A S
S E
C S
U
L
A
R
D
I
S
C
E
GITTER CELLS
R
E
B
R
O E
V A
A S
S E
C S
U
L
A
R
D
I
S
Many things can go wrong
? How do the organisms get into the brain or its meninges??
I
Hematogenous spread
N
F
Arterial
Venous
E
Local extension
C
T
I
Direct implantation
O
N
S
Through nerves
Terminology
I
? Acute Vs Subacute Vs Chronic
Acute bacterial/pyogenic
meningitis
N
? Causative organism
F
? Bacterial
Chronic bacterial meningitis
E
? Viral
C
? Fungal
? protozoal
T
Chronic bacterial meningitis
I
? Compartment affected
? Meningitis
O
? Encephalitis
Acute aseptic meningitis
N
? Meningo-encephalitis
S
? Nature of involvement
? Focal
Viral encephalitis
? Diffuse
Clinical presentation
I
N
? Systemic signs of infection with
F
? Meningeal irritation
Waterhouse Friderichsen syndrome:
Meningitis
E
? Neurological impairment
Septicemia
C
? Headache
Adrenal gland hemorrhagic infarction
T
? Photophobia
Meningococcal meningitis
I
? Irritability
Pneumococcal meningitis
O
? Clouding of consciousness
N
? Neck stiffness
S
Acute pyogenic meningitis
I
N
F
E
C
T
I
O
N
S
LESS SEVERE
BUT LONG TERM SEQUELAE
I
N
F
E
C
T
I
O
N
S
HERPES SIMPLEX VIRUS
ENCEPHALITIS
I
N
F
E
C
T
I
O
N
S
VIRAL
INCLUSIONS
I
N
F
E
C
T
I
O
N
S
I
N
F
E
C
T
I
O
N
S
I
N
F
E
C
T
I
O
N
S
I
N
F
E
C
T
I
O
N
S
Prion disease
I
? Proteinaceous infectious particle
N
F
? Spongiform encephalopathy
E
C
? Creutzfeldt Jacob disease
T
? Fatal Familial Insomnia
I
O
? Bovine Spongiform encephalopathy
N
? Kuru
S
I
N
F
E
C
T
I
O
N
S
D
MULTIPLE
E
SCLEROSIS
M
Y
E
L
I
N S
A E
T S
I
N
G
D
I
S
E
A
N
E
U
R
O
D I
E S
G E
E
PLAQUE
A
ALZHIEMERS
N S
E E
R S
A
T
I
V
E
NEUROFIBRILLARY TANGLE
DN
E
U
R
O
D I
E S
G E
E A
N S
E E
R S
A
T
I
PARKINSONS
V
E
D
Questions which have been asked.
This post was last modified on 07 April 2022