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Download MBBS Pathology PPT 12 Obstructive Jaundice Pathophysiology Lecture Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) Pathology PPT 12 Obstructive Jaundice Pathophysiology Lecture Notes

This post was last modified on 07 April 2022




Pathophysiology: Obstructive

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jaundice

MRP2/ABCC2

INTRA-HEPATIC

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EXTRA-HEPATIC


INFECTIONS

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HEPATOCYTES

INFLAMMATION:

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? Viral hepatitis

Autoimmune

? Alcoholic hepatitis

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DRUG INDUCED

? Drug induced

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? Sepsis

Centrilobular

CONGENITAL/INHERITED

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? Progressive familial

INTRAHEPATIC

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BILE DUCTS

? Primary Biliary

intrahepatic

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causes

Periportal

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cirrhosis

cholestasis

? Primary sclerosing

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? Benign recurrent

cholangitis

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cholestasis

? Vanishing bile duct

syndrome

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INFILTRATION

? Amyloidosis

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? Tuberculosis

? Lymphoma


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INSIDE THE LUMEN

IN THE WALL

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PRESSURE FROM OUTSIDE

NORMAL HISTOLOGY

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GENERAL CHOLESTASIS FEATURES

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FEATHERY DEGENERATION

Robbins Pathological Basis of Disease, 9th edition

GENERAL CHOLESTASIS FEATURES

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Robbins Pathological Basis of Disease, 9th edition


AUTOIMMUNE

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CHOLANGIOPATHIES

Robbins Pathological Basis of Disease, 9th edition

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PRIMARY BILIARY CIRRHOSIS

? SMALL & MEDIUM SIZE DUCTS
? NON-SUPPURATIVE
? EXTRA HEPATIC BILIARY TREE NOT

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INVOLVED

? PATCHY INVOLVEMENT

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" FLORID DUCT LESION"

Robbins Pathological Basis of Disease, 9th edition


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PRIMARY SCLEROSING CHOLANGITIS

? BOTH INTRA & EXTRA HEPATIC DUCTS

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? INFLAMMTION & SCLEROSIS
? INTERMITTENT SEGMENTS DILATED
? ULCERATIVE COLITIS

"ONION SKIN" FIBROSIS

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NORMAL

MR CHOLANGIOGRAM: "BEADING"

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Robbins Pathological Basis of Disease, 9th edition

BILE DUCT SCAR FORMATION

"ONION SKIN" FIBROSIS

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SPOT THE DIFFERENCES

BILIARY CIRRHOSIS

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SPECIAL CASE IN NEONATES

NEONATAL

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EXTRA HEPATIC

HEPATITIS

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BILIARY ATRESIA

NOT A SINGLE DISEASE

OBSTRUCTIVE CAUSE

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NOT NECESSARILY INFLAMMATORY

INFLAMMATION & FIBROSIS

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TOXIC, METABOLIC, INFECTIOUS,

IDIOPATHIC

SURGICAL TREATMENT: KASAI

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NON- OBSTRUCTIVE

VERY IMPORTANT TO DIFFERENTIATE THE

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TWO!

NEONATAL HEPATITIS

EHBA

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EHBA

Robbins Pathological Basis of Disease, 9th edition

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AMYLOIDOSIS

Summary

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? Causes

? Intra: Hepatocytes, Bile ducts, Portal tract

? Extra: Benign, Malignant

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? NEONATES

? Neonatal Hepatitis

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? EHBA

? Early phases: Reversible

? Late stages: Biliary cirrhosis Irreversible

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