Download MBBS Pathology PPT 13 Pathogenesis Of Rheumatoid Arthritis Lecture Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) Pathology PPT 13 Pathogenesis Of Rheumatoid Arthritis Lecture Notes

Pathogenesis and Pathology of

Rheumatoid Arthritis

"Rheumatoid" : Why?

? Rheum : flow

~ oid: resembling

Serum

Phlegm

? Attributed to humors

Blood

? Hippocrates

Black bile

? 4 bodily fluids

? Increased substance flows and settles in joints

rheumatism

? Paracelsus (1493-1511): substances that could not be

passed in urine precipitated in joints, and caused

arthritis.

? Autoimmune disease






? Where do the antibodies/ Ag-ab

complexes come from?

? Molecular mimicry?

? Environmental triggers leading

to citrul ination of self

proteins? new epitopes?

Anti-ccp antibodies

"cyclic citrul inated peptide"

? Rheumatoid factor

(autoantibody against Fc

portion of IgG)

? HLA-DRB1 al eles present

arthritogen?


Lumen




? What do the Antigen antibody

complexes contain?

? Citrullinated fibrinogen

? Enolase

? Collagen

? Vimentin

? Why are some joints affected

more commonly than others?

SUMMARY

50% risk

attributable

IL-17

IFN

Macrophage

TNF

IL-1


Synovium

Cartilage

Papil ae

Synovial hyperplasia

Lymphoid follicles

Normal Synovium




papil ae

Synovial hyperplasia

Normal Synovium

Synovial hyperplasia

Plasma cel s


Rheumatoid nodule

Fibrinoid necrosis

Palisading histiocytes

Palisading histiocytes

Fibrinoid necrosis
Points to remember

? Anti ? ccp antibodies
? Rheumatoid factor
? HLA-DRB1 alleles
? Pannus formation

? Synovial hyperplasia, lymphoid follicles, plasma cells

? Fibrin

? Rheumatoid nodule

? Necrosis with palisading histiocytes

? Differences between Rheumatoid and Osteoarthritis