"Rheumatoid" : Why?
? Rheum : flow
--- Content provided by FirstRanker.com ---
~ oid: resembling
Serum
--- Content provided by FirstRanker.com ---
Phlegm? Attributed to humors
Blood
--- Content provided by FirstRanker.com ---
? Hippocrates
Black bile
--- Content provided by FirstRanker.com ---
? 4 bodily fluids? Increased substance flows and settles in joints
rheumatism
--- Content provided by FirstRanker.com ---
? Paracelsus (1493-1511): substances that could not be
passed in urine precipitated in joints, and caused
--- Content provided by FirstRanker.com ---
arthritis.? Autoimmune disease
--- Content provided by FirstRanker.com ---
? Where do the antibodies/ Ag-ab
--- Content provided by FirstRanker.com ---
complexes come from?
? Molecular mimicry?
--- Content provided by FirstRanker.com ---
? Environmental triggers leadingto citrul ination of self
proteins? new epitopes?
--- Content provided by FirstRanker.com ---
Anti-ccp antibodies
"cyclic citrul inated peptide"
--- Content provided by FirstRanker.com ---
? Rheumatoid factor(autoantibody against Fc
portion of IgG)
--- Content provided by FirstRanker.com ---
? HLA-DRB1 al eles present
arthritogen?
--- Content provided by FirstRanker.com ---
Lumen
--- Content provided by FirstRanker.com ---
? What do the Antigen antibody
complexes contain?
--- Content provided by FirstRanker.com ---
? Citrullinated fibrinogen? Enolase
? Collagen
--- Content provided by FirstRanker.com ---
? Vimentin
? Why are some joints affected
--- Content provided by FirstRanker.com ---
more commonly than others?SUMMARY
50% risk
--- Content provided by FirstRanker.com ---
attributable
IL-17
--- Content provided by FirstRanker.com ---
IFNMacrophage
TNF
--- Content provided by FirstRanker.com ---
IL-1
Synovium
--- Content provided by FirstRanker.com ---
Cartilage
Papil ae
--- Content provided by FirstRanker.com ---
Synovial hyperplasiaLymphoid follicles
Normal Synovium
--- Content provided by FirstRanker.com ---
papil ae
--- Content provided by FirstRanker.com ---
Synovial hyperplasia
Normal Synovium
--- Content provided by FirstRanker.com ---
Synovial hyperplasiaPlasma cel s
--- Content provided by FirstRanker.com ---
Rheumatoid noduleFibrinoid necrosis
Palisading histiocytes
--- Content provided by FirstRanker.com ---
Palisading histiocytes
Fibrinoid necrosis
Points to remember
--- Content provided by FirstRanker.com ---
? Anti ? ccp antibodies
? Rheumatoid factor
? HLA-DRB1 alleles
? Pannus formation
--- Content provided by FirstRanker.com ---
? Synovial hyperplasia, lymphoid follicles, plasma cells
? Fibrin
--- Content provided by FirstRanker.com ---
? Rheumatoid nodule? Necrosis with palisading histiocytes
? Differences between Rheumatoid and Osteoarthritis
--- Content provided by FirstRanker.com ---