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Total No. of Questions : 06
M.Pharmacy(Industrial Pharmacy) (2017 Batch) (Sem.-2)
ADVANCED BIOPHARMACEUTICS AND PHARMACOKINETICS
Subject Code : MIP-201T
M.Code: 74931
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Time: 3 Hrs.
Max. Marks : 75
INSTRUCTIONS TO CANDIDATES :
- Attempt any FIVE questions out of SIX questions.
- Each question carries FIFTEEN marks.
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- a. Name various theories explaining drug dissolution and enlist the factors affecting dissolution rate. (8)
b. Discuss the limitations and significance of pH-partition hypothesis. (7) - Discuss various methods used for bioavailability enhancement by enhancing permeability of drugs. (15)
- a. What are merits and demerits of Wagner-Nelson method in computing Ka? (5)
b. What is flip-flop phenomenon and when is it observed? (5)--- Content provided by FirstRanker.com ---
c. Elaborate the type of compartmental models. Why catenary model is less useful than mammillary model? (5) - a. What are various types of bioequivalence studies? (8)
b. State the plateau principle. Which parameters govern attainment of steady-state? (7) - Write short notes on the following:
a. Discuss the pharmacokinetics of modified-release drug products. (8)--- Content provided by FirstRanker.com ---
b. What are the various compendial dissolution apparatus designs? Discuss briefly stating their applications. (7) - Discuss the following with suitable examples :
a. Statistical moments theory. (5)
b. Cross over & carry over study design . (5)
c. Plasma half life (t1/2), AUC & AUMC. (5)
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NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.
1| M-74931 (S31)-350
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