Download PTU M-Pharma 2019 May 2nd Semester 74945 PRINCIPLES OF DRUG DISCOVERY Question Paper

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Roll No.

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Total No. of Questions : 06

Total No. of Pages : 01

M.Pharmacy(Pharmacology) (2017 Batch) (Sem.-2)

PRINCIPLES OF DRUG DISCOVERY

Subject Code : MPL-203T

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M.Code: 74945

Time: 3 Hrs.

Max. Marks: 75

INSTRUCTIONS TO CANDIDATES :

1. Attempt any FIVE questions out of SIX questions.

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2. Each question carries FIFTEEN marks.

1. How will you discover a new drug for Hypertension? Discuss various steps with suitable diagram and/or flowcharts. 15
2. 1. Discuss the concept of molecular docking. 7
   2. Write a note on 3D-QSAR & hit identification. 8

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3. Write short notes on : 5×3
   1. Protein microarray
   2. Bioinformatics
   3. Pharmacophore
4. Write short notes on the following : 5x3
   1. Drug likeliness

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   2. Prodrug design
   3. Application of NMR in protein structure prediction
5. Discuss rational drug design with suitable examples and/or flow charts. 15
6. Discuss the identification and validation of the following with suitable examples :
   1. Target 7

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   2. Lead 8

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.