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Download PTU M-Pharma 2019 May 2nd Semester 74957 COMPUTER AIDED DRUG DESIGN Question Paper

Download PTU (Punjab Technical University) M-Pharma (Master of Pharmacy) 2nd Semester 74957 COMPUTER AIDED DRUG DESIGN Last 10 Years 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011 and 2010 Previous Question Papers.

This post was last modified on 07 December 2019

PTU M.Pharm (Master of Pharmacy) 2nd Semester Last 10 Years 2010-2020 Previous Question Papers|| Punjab Technical University


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Roll No.

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Total No. of Pages : 01

Total No. of Questions : 06

M.Pharma(Pharmaceutical Chemistry)(2017 & Onwards) (Sem.-2)

COMPUTER AIDED DRUG DESIGN

Subject Code : MPC-203T

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Time: 3 Hrs.

M.Code: 74957

Max. Marks: 75

INSTRUCTIONS TO CANDIDATES :

  1. Attempt any FIVE questions out of SIX questions.
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  3. Each question carries FIFTEEN marks.
    1. Briefly explain Lipinsky's Rule of five. (7)
    2. What do you mean by term preADME. Discuss the significance of preADME prediction in drug discovery process. (8)
    1. Write short note on Fragment based Denovo drug designing. (5)
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    3. Write a short note on global energy minimization. (5)
    4. Briefly explain Craig plot. (5)
    1. Explain in detail Homology modelling and the method adopted for the generation of the 3D structure of a protein. (7)
    2. Give a detailed account of mapping. (8)
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    1. Explain Topliss Decision Tree for aromatic substituents in deciding on newer analogues with improved biological activity. (5)
    2. Discuss Structure based in silico virtual screening. (5)
    3. Discuss different Statistical approached used in QSAR. (5)
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  2. Enumerate the different physicochemical properties of a drug molecule that influence the biological activity and describe in detail about hydrogen bonding and ionization influences on biological activity. (15)
  3. Define and classify QSAR with their advantages. Elaborate on the multi-parametric approach to QSAR as enunciated by Hansch. (15)

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.

1| M-74957

(S31)-1314

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