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Total No. of Pages : 01
Total No. of Questions : 06
M.Pharma(Pharmaceutical Chemistry)(2017 & Onwards) (Sem.-2)
COMPUTER AIDED DRUG DESIGN
Subject Code : MPC-203T
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Time: 3 Hrs.
M.Code: 74957
Max. Marks: 75
INSTRUCTIONS TO CANDIDATES :
- Attempt any FIVE questions out of SIX questions.
- Each question carries FIFTEEN marks.
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- Briefly explain Lipinsky's Rule of five. (7)
- What do you mean by term preADME. Discuss the significance of preADME prediction in drug discovery process. (8)
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- Write short note on Fragment based Denovo drug designing. (5)
- Write a short note on global energy minimization. (5)
- Briefly explain Craig plot. (5)
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- Explain in detail Homology modelling and the method adopted for the generation of the 3D structure of a protein. (7)
- Give a detailed account of mapping. (8)
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- Explain Topliss Decision Tree for aromatic substituents in deciding on newer analogues with improved biological activity. (5)
- Discuss Structure based in silico virtual screening. (5)
- Discuss different Statistical approached used in QSAR. (5)
- Enumerate the different physicochemical properties of a drug molecule that influence the biological activity and describe in detail about hydrogen bonding and ionization influences on biological activity. (15)
- Define and classify QSAR with their advantages. Elaborate on the multi-parametric approach to QSAR as enunciated by Hansch. (15)
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NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.
1| M-74957
(S31)-1314
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This download link is referred from the post: PTU M.Pharm (Master of Pharmacy) 2nd Semester Last 10 Years 2010-2020 Previous Question Papers|| Punjab Technical University
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